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Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study.

Publication ,  Journal Article
Shah, NH; Dong, C; Elkind, MSV; Sacco, RL; Mendez, AJ; Hudson, BI; Silverberg, S; Wolf, M; Rundek, T; Wright, CB
Published in: Arterioscler Thromb Vasc Biol
September 2015

OBJECTIVE: Elevated fibroblast growth factor 23 (FGF23), a hormone that regulates phosphate homeostasis, has been associated with mortality, cardiovascular events, and stroke, and to arterial calcification in chronic kidney disease, but its role in atherosclerosis is unclear and population-based studies are lacking. We hypothesized that elevated FGF23 would associate with carotid plaque presence, area, and echogenicity in the race/ethnically diverse community-based Northern Manhattan Study (NOMAS) sample. APPROACH AND RESULTS: There were 1512 stroke-free NOMAS participants with FGF23 and 2-dimensional carotid ultrasound data (mean age, 68±9 years; 61% women; 62% Hispanic, 18% black, and 18% white). We used multivariable linear and logistic regression to evaluate FGF23, continuously and by quintiles, as a correlate of carotid plaque, plaque area (cubic root transformed), and echogenicity adjusting for sociodemographic and vascular risk factors. Participants with FGF23 levels in the top quintile were more likely to have carotid plaque (odds ratio, 1.49; 95% confidence interval, 1.02-2.19; P=0.04) and larger plaque area (β=0.32 mm(2), 95% confidence interval, 0.10-0.53 mm(2); P=0.004) than those in the lowest quintile, adjusting for estimated glomerular filtration rate, demographics, and vascular risk factors. Linear regression models also showed that log transformed FGF23 (LnFGF23) associated with greater odds of plaque presence (odds ratio, 1.26 per LnFGF23; 95% confidence interval, 1.01-1.58; P=0.04), and plaque area (β=0.19 mm(2) per LnFGF23; 95% confidence interval, 0.07-0.31 mm(2); P=0.002). CONCLUSIONS: Higher FGF23 associated with greater likelihood and burden of carotid atherosclerosis independent of CKD. Atherosclerosis may be a mechanism through which FGF23 increases cardiovascular events and stroke.

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Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

September 2015

Volume

35

Issue

9

Start / End Page

2048 / 2053

Location

United States

Related Subject Headings

  • Urban Population
  • Ultrasonography
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • ROC Curve
  • Plaque, Atherosclerotic
  • Odds Ratio
  • New York City
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shah, N. H., Dong, C., Elkind, M. S. V., Sacco, R. L., Mendez, A. J., Hudson, B. I., … Wright, C. B. (2015). Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study. Arterioscler Thromb Vasc Biol, 35(9), 2048–2053. https://doi.org/10.1161/ATVBAHA.115.305945
Shah, Nirav H., Chuanhui Dong, Mitchell S. V. Elkind, Ralph L. Sacco, Armando J. Mendez, Barry I. Hudson, Shonni Silverberg, Myles Wolf, Tatjana Rundek, and Clinton B. Wright. “Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study.Arterioscler Thromb Vasc Biol 35, no. 9 (September 2015): 2048–53. https://doi.org/10.1161/ATVBAHA.115.305945.
Shah NH, Dong C, Elkind MSV, Sacco RL, Mendez AJ, Hudson BI, et al. Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2048–53.
Shah, Nirav H., et al. “Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study.Arterioscler Thromb Vasc Biol, vol. 35, no. 9, Sept. 2015, pp. 2048–53. Pubmed, doi:10.1161/ATVBAHA.115.305945.
Shah NH, Dong C, Elkind MSV, Sacco RL, Mendez AJ, Hudson BI, Silverberg S, Wolf M, Rundek T, Wright CB. Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and Area: The Northern Manhattan Study. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2048–2053.

Published In

Arterioscler Thromb Vasc Biol

DOI

EISSN

1524-4636

Publication Date

September 2015

Volume

35

Issue

9

Start / End Page

2048 / 2053

Location

United States

Related Subject Headings

  • Urban Population
  • Ultrasonography
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • ROC Curve
  • Plaque, Atherosclerotic
  • Odds Ratio
  • New York City
  • Middle Aged