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Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients.

Publication ,  Journal Article
Troost, JP; Gipson, DS; Carlozzi, NE; Reeve, BB; Nachman, PH; Gbadegesin, R; Wang, J; Modersitzki, F; Massengill, S; Mahan, JD; Liu, Y ...
Published in: Health Psychol
May 2019

OBJECTIVE: Nephrotic syndrome (NS) is a kidney disease known to adversely impact health-related quality of life (HRQOL). Patient-reported outcome (PRO) measures are commonly used to characterize HRQOL and the patient disease experience. This study aims to improve the interpretability and clinical utility of the Patient-Reported Outcomes Measurement Information System® (PROMIS®) by identifying distinct meaningful HRQOL profiles in children and adults with NS. METHOD: Patients were from 2 prospective NS cohort studies (PROMIS-II®: 121 children; NEPTUNE: 40 children and 219 adults) with data from 6 PROMIS® domains. Latent Profile Analysis was used to identify subgroups of patients based on PROMIS® score patterns. A 3-step analysis of latent profile predictors was used to determine how clinical parameters predicted HRQOL profile membership. RESULTS: We identified 3 HRQOL profiles (Good, Average, and Poor) with strong indicators of membership classification (entropy >0.86). Complete proteinuria remission, reduction in symptoms, and shorter disease duration, were significant predictors of better HRQOL profile membership. CONCLUSIONS: Patients with NS can be classified by HRQOL into clinically meaningful categories. Integrating this approach into clinic may help in the identification of individuals with poor HRQOL will help clinicians better manage their symptoms and researchers study the causes and possible interventions for these patients. PROMIS® HRQOL profiles were reproducible in replication cohorts. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Duke Scholars

Published In

Health Psychol

DOI

EISSN

1930-7810

Publication Date

May 2019

Volume

38

Issue

5

Start / End Page

410 / 421

Location

United States

Related Subject Headings

  • Young Adult
  • Quality of Life
  • Public Health
  • Patient Reported Outcome Measures
  • Nephrotic Syndrome
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Troost, J. P., Gipson, D. S., Carlozzi, N. E., Reeve, B. B., Nachman, P. H., Gbadegesin, R., … Selewski, D. T. (2019). Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients. Health Psychol, 38(5), 410–421. https://doi.org/10.1037/hea0000679
Troost, Jonathan P., Debbie S. Gipson, Noelle E. Carlozzi, Bryce B. Reeve, Patrick H. Nachman, Rasheed Gbadegesin, Jichuan Wang, et al. “Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients.Health Psychol 38, no. 5 (May 2019): 410–21. https://doi.org/10.1037/hea0000679.
Troost JP, Gipson DS, Carlozzi NE, Reeve BB, Nachman PH, Gbadegesin R, et al. Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients. Health Psychol. 2019 May;38(5):410–21.
Troost, Jonathan P., et al. “Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients.Health Psychol, vol. 38, no. 5, May 2019, pp. 410–21. Pubmed, doi:10.1037/hea0000679.
Troost JP, Gipson DS, Carlozzi NE, Reeve BB, Nachman PH, Gbadegesin R, Wang J, Modersitzki F, Massengill S, Mahan JD, Liu Y, Trachtman H, Herreshoff EG, DeWalt DA, Selewski DT. Using PROMIS® to create clinically meaningful profiles of nephrotic syndrome patients. Health Psychol. 2019 May;38(5):410–421.

Published In

Health Psychol

DOI

EISSN

1930-7810

Publication Date

May 2019

Volume

38

Issue

5

Start / End Page

410 / 421

Location

United States

Related Subject Headings

  • Young Adult
  • Quality of Life
  • Public Health
  • Patient Reported Outcome Measures
  • Nephrotic Syndrome
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Cohort Studies