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Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.

Publication ,  Journal Article
Hornik, CP; Atz, AM; Bendel, C; Chan, F; Downes, K; Grundmeier, R; Fogel, B; Gipson, D; Laughon, M; Miller, M; Smith, M; Livingston, C ...
Published in: Appl Clin Inform
March 2019

BACKGROUND: Integration of electronic health records (EHRs) data across sites and access to that data remain limited. OBJECTIVE: We developed an EHR-based pediatric inpatient repository using nine U.S. centers from the National Institute of Child Health and Human Development Pediatric Trials Network. METHODS: A data model encompassing 147 mandatory and 99 optional elements was developed to provide an EHR data extract of all inpatient encounters from patients <17 years of age discharged between January 6, 2013 and June 30, 2017. Sites received instructions on extractions, transformation, testing, and transmission to the coordinating center. RESULTS: We generated 177 staging reports to process all nine sites' 147 mandatory and 99 optional data elements to the repository. Based on 520 prespecified criteria, all sites achieved 0% errors and <2% warnings. The repository includes 386,159 inpatient encounters from 264,709 children to support study design and conduct of future trials in children. CONCLUSION: Our EHR-based data repository of pediatric inpatient encounters utilized a customized data model heavily influenced by the PCORnet format, site-based data mapping, a comprehensive set of data testing rules, and an iterative process of data submission. The common data model, site-based extraction, and technical expertise were key to our success. Data from this repository will be used in support of Pediatric Trials Network studies and the labeling of drugs and devices for children.

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Published In

Appl Clin Inform

DOI

EISSN

1869-0327

Publication Date

March 2019

Volume

10

Issue

2

Start / End Page

307 / 315

Location

Germany

Related Subject Headings

  • Male
  • Inpatients
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Electronic Health Records
  • Databases, Factual
  • Clinical Trials as Topic
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
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Hornik, C. P., Atz, A. M., Bendel, C., Chan, F., Downes, K., Grundmeier, R., … Best Pharmaceuticals for Children Act–Pediatric Trials Network. (2019). Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records. Appl Clin Inform, 10(2), 307–315. https://doi.org/10.1055/s-0039-1688477
Hornik, Christoph P., Andrew M. Atz, Catherine Bendel, Francis Chan, Kevin Downes, Robert Grundmeier, Ben Fogel, et al. “Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.Appl Clin Inform 10, no. 2 (March 2019): 307–15. https://doi.org/10.1055/s-0039-1688477.
Hornik CP, Atz AM, Bendel C, Chan F, Downes K, Grundmeier R, et al. Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records. Appl Clin Inform. 2019 Mar;10(2):307–15.
Hornik, Christoph P., et al. “Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.Appl Clin Inform, vol. 10, no. 2, Mar. 2019, pp. 307–15. Pubmed, doi:10.1055/s-0039-1688477.
Hornik CP, Atz AM, Bendel C, Chan F, Downes K, Grundmeier R, Fogel B, Gipson D, Laughon M, Miller M, Smith M, Livingston C, Kluchar C, Heath A, Jarrett C, McKerlie B, Patel H, Hunter C, Best Pharmaceuticals for Children Act–Pediatric Trials Network. Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records. Appl Clin Inform. 2019 Mar;10(2):307–315.
Journal cover image

Published In

Appl Clin Inform

DOI

EISSN

1869-0327

Publication Date

March 2019

Volume

10

Issue

2

Start / End Page

307 / 315

Location

Germany

Related Subject Headings

  • Male
  • Inpatients
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Electronic Health Records
  • Databases, Factual
  • Clinical Trials as Topic
  • Child, Preschool