Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences.

Publication ,  Journal Article
Price, D; Tyler, LK; Neto Henriques, R; Campbell, KL; Williams, N; Treder, MS; Taylor, JR; Cam-CAN, ; Henson, RNA
Published in: Nat Commun
June 9, 2017

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 9, 2017

Volume

8

Start / End Page

15671

Location

England

Related Subject Headings

  • Young Adult
  • White Matter
  • Vision, Ocular
  • Time Factors
  • Principal Component Analysis
  • Models, Neurological
  • Middle Aged
  • Male
  • Magnetoencephalography
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Price, D., Tyler, L. K., Neto Henriques, R., Campbell, K. L., Williams, N., Treder, M. S., … Henson, R. N. A. (2017). Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences. Nat Commun, 8, 15671. https://doi.org/10.1038/ncomms15671
Price, D., L. K. Tyler, R. Neto Henriques, K. L. Campbell, N. Williams, M. S. Treder, J. R. Taylor, J. R. Cam-CAN, and R. N. A. Henson. “Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences.Nat Commun 8 (June 9, 2017): 15671. https://doi.org/10.1038/ncomms15671.
Price D, Tyler LK, Neto Henriques R, Campbell KL, Williams N, Treder MS, et al. Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences. Nat Commun. 2017 Jun 9;8:15671.
Price, D., et al. “Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences.Nat Commun, vol. 8, June 2017, p. 15671. Pubmed, doi:10.1038/ncomms15671.
Price D, Tyler LK, Neto Henriques R, Campbell KL, Williams N, Treder MS, Taylor JR, Cam-CAN, Henson RNA. Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences. Nat Commun. 2017 Jun 9;8:15671.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 9, 2017

Volume

8

Start / End Page

15671

Location

England

Related Subject Headings

  • Young Adult
  • White Matter
  • Vision, Ocular
  • Time Factors
  • Principal Component Analysis
  • Models, Neurological
  • Middle Aged
  • Male
  • Magnetoencephalography
  • Magnetic Resonance Imaging