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Multimodal characterization of the human nucleus accumbens.

Publication ,  Journal Article
Cartmell, SC; Tian, Q; Thio, BJ; Leuze, C; Ye, L; Williams, NR; Yang, G; Ben-Dor, G; Deisseroth, K; Grill, WM; McNab, JA; Halpern, CH
Published in: NeuroImage
September 2019

Dysregulation of the nucleus accumbens (NAc) is implicated in numerous neuropsychiatric disorders. Treatments targeting this area directly (e.g. deep brain stimulation) demonstrate variable efficacy, perhaps owing to non-specific targeting of a functionally heterogeneous nucleus. Here we provide support for this notion, first observing disparate behavioral effects in response to direct simulation of different locations within the NAc in a human patient. These observations motivate a segmentation of the NAc into subregions, which we produce from a diffusion-tractography based analysis of 245 young, unrelated healthy subjects. We further explore the mechanism of these stimulation-induced behavioral responses by identifying the most probable subset of axons activated using a patient-specific computational model. We validate our diffusion-based segmentation using evidence from several modalities, including MRI-based measures of function and microstructure, human post-mortem immunohistochemical staining, and cross-species comparison of cortical-NAc projections that are known to be conserved. Finally, we visualize the passage of individual axon bundles through one NAc subregion in a post-mortem human sample using CLARITY 3D histology corroborated by 7T tractography. Collectively, these findings extensively characterize human NAc subregions and provide insight into their structural and functional distinctions with implications for stereotactic treatments targeting this region.

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Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

September 2019

Volume

198

Start / End Page

137 / 149

Related Subject Headings

  • Nucleus Accumbens
  • Neurology & Neurosurgery
  • Neural Pathways
  • Models, Neurological
  • Mice
  • Male
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Electric Stimulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cartmell, S. C., Tian, Q., Thio, B. J., Leuze, C., Ye, L., Williams, N. R., … Halpern, C. H. (2019). Multimodal characterization of the human nucleus accumbens. NeuroImage, 198, 137–149. https://doi.org/10.1016/j.neuroimage.2019.05.019
Cartmell, Samuel Cd, Qiyuan Tian, Brandon J. Thio, Christoph Leuze, Li Ye, Nolan R. Williams, Grant Yang, et al. “Multimodal characterization of the human nucleus accumbens.NeuroImage 198 (September 2019): 137–49. https://doi.org/10.1016/j.neuroimage.2019.05.019.
Cartmell SC, Tian Q, Thio BJ, Leuze C, Ye L, Williams NR, et al. Multimodal characterization of the human nucleus accumbens. NeuroImage. 2019 Sep;198:137–49.
Cartmell, Samuel Cd, et al. “Multimodal characterization of the human nucleus accumbens.NeuroImage, vol. 198, Sept. 2019, pp. 137–49. Epmc, doi:10.1016/j.neuroimage.2019.05.019.
Cartmell SC, Tian Q, Thio BJ, Leuze C, Ye L, Williams NR, Yang G, Ben-Dor G, Deisseroth K, Grill WM, McNab JA, Halpern CH. Multimodal characterization of the human nucleus accumbens. NeuroImage. 2019 Sep;198:137–149.
Journal cover image

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

September 2019

Volume

198

Start / End Page

137 / 149

Related Subject Headings

  • Nucleus Accumbens
  • Neurology & Neurosurgery
  • Neural Pathways
  • Models, Neurological
  • Mice
  • Male
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Electric Stimulation