Scholars@Duke publication: Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Publication , Journal Article

Xue, R; Chen, L; Zhang, C; Fujita, M; Li, R; Yan, S-M; Ong, CK; Liao, X; Gao, Q; Sasagawa, S; Li, Y; Wang, J; Guo, H; Huang, Q-T; Zhong, Q ...

Published in: Cancer Cell

June 2019

Published version (DOI)

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.

Duke Scholars

Author Steven George Rozen Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

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Published In

Cancer Cell

DOI

10.1016/j.ccell.2019.04.007

EISSN

1878-3686

ISSN

1535-6108

Publication Date

June 2019

Volume

Issue

Start / End Page

932 / 947.e8

Related Subject Headings

Up-Regulation
Transcriptome
Prognosis
Predictive Value of Tests
Oncology & Carcinogenesis
Nestin
Neoplasms, Complex and Mixed
Male
Liver Neoplasms
Immunohistochemistry

Citation

APA

Chicago

ICMJE

MLA

NLM

Xue, R., Chen, L., Zhang, C., Fujita, M., Li, R., Yan, S.-M., … Zhang, N. (2019). Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell, 35(6), 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007

Xue, Ruidong, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.” Cancer Cell 35, no. 6 (June 2019): 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007.

Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, et al. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun;35(6):932-947.e8.

Xue, Ruidong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.” Cancer Cell, vol. 35, no. 6, June 2019, pp. 932-947.e8. Epmc, doi:10.1016/j.ccell.2019.04.007.

Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang Q-T, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng M-S, Bai F, Zhang N. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun;35(6):932-947.e8.

Published In

Cancer Cell

DOI

10.1016/j.ccell.2019.04.007

EISSN

1878-3686

ISSN

1535-6108

Publication Date

June 2019

Volume

Issue

Start / End Page

932 / 947.e8

Related Subject Headings

Up-Regulation
Transcriptome
Prognosis
Predictive Value of Tests
Oncology & Carcinogenesis
Nestin
Neoplasms, Complex and Mixed
Male
Liver Neoplasms
Immunohistochemistry