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Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Publication ,  Journal Article
Xue, R; Chen, L; Zhang, C; Fujita, M; Li, R; Yan, S-M; Ong, CK; Liao, X; Gao, Q; Sasagawa, S; Li, Y; Wang, J; Guo, H; Huang, Q-T; Zhong, Q ...
Published in: Cancer Cell
June 10, 2019
Published version (DOI) Link to item

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.

Duke Scholars

Steven George Rozen
Author Steven George Rozen Biostatistics & Bioinformatics, Division of Integrative Geno ...
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Published In

Cancer Cell

DOI

10.1016/j.ccell.2019.04.007

EISSN

1878-3686

Publication Date

June 10, 2019

Volume

35

Issue

6

Start / End Page

932 / 947.e8

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcriptome
  • Prognosis
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Nestin
  • Neoplasms, Complex and Mixed
  • Male
  • Liver Neoplasms
  • Immunohistochemistry
 

Citation

APA
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ICMJE
MLA
NLM
Xue, R., Chen, L., Zhang, C., Fujita, M., Li, R., Yan, S.-M., … Zhang, N. (2019). Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell, 35(6), 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007
Xue, Ruidong, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.” Cancer Cell 35, no. 6 (June 10, 2019): 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, et al. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.e8.
Xue, Ruidong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.” Cancer Cell, vol. 35, no. 6, June 2019, pp. 932-947.e8. Pubmed, doi:10.1016/j.ccell.2019.04.007.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang Q-T, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng M-S, Bai F, Zhang N. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.e8.
Journal cover image

Published In

Cancer Cell

DOI

10.1016/j.ccell.2019.04.007

EISSN

1878-3686

Publication Date

June 10, 2019

Volume

35

Issue

6

Start / End Page

932 / 947.e8

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcriptome
  • Prognosis
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Nestin
  • Neoplasms, Complex and Mixed
  • Male
  • Liver Neoplasms
  • Immunohistochemistry