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Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Publication ,  Journal Article
Xue, R; Chen, L; Zhang, C; Fujita, M; Li, R; Yan, S-M; Ong, CK; Liao, X; Gao, Q; Sasagawa, S; Li, Y; Wang, J; Guo, H; Huang, Q-T; Zhong, Q ...
Published in: Cancer Cell
June 2019

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

ISSN

1535-6108

Publication Date

June 2019

Volume

35

Issue

6

Start / End Page

932 / 947.e8

Related Subject Headings

  • Up-Regulation
  • Transcriptome
  • Prognosis
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Nestin
  • Neoplasms, Complex and Mixed
  • Male
  • Liver Neoplasms
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xue, R., Chen, L., Zhang, C., Fujita, M., Li, R., Yan, S.-M., … Zhang, N. (2019). Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell, 35(6), 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007
Xue, Ruidong, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.Cancer Cell 35, no. 6 (June 2019): 932-947.e8. https://doi.org/10.1016/j.ccell.2019.04.007.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, et al. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun;35(6):932-947.e8.
Xue, Ruidong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.Cancer Cell, vol. 35, no. 6, June 2019, pp. 932-947.e8. Epmc, doi:10.1016/j.ccell.2019.04.007.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan S-M, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang Q-T, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng M-S, Bai F, Zhang N. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. Cancer Cell. 2019 Jun;35(6):932-947.e8.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

ISSN

1535-6108

Publication Date

June 2019

Volume

35

Issue

6

Start / End Page

932 / 947.e8

Related Subject Headings

  • Up-Regulation
  • Transcriptome
  • Prognosis
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Nestin
  • Neoplasms, Complex and Mixed
  • Male
  • Liver Neoplasms
  • Immunohistochemistry