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The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation.

Publication ,  Journal Article
Gomez, DR; Rimner, A; Simone, CB; Cho, BCJ; de Perrot, M; Adjei, AA; Bueno, R; Gill, RR; Harpole, DH; Hesdorffer, M; Hirsch, FR; Jackson, AA ...
Published in: J Thorac Oncol
July 2019

INTRODUCTION: Detailed guidelines regarding the use of radiation therapy for malignant pleural mesothelioma (MPM) are currently lacking because of the rarity of the disease, the wide spectrum of clinical presentations, and the paucity of high-level data on individual treatment approaches. METHODS: In March 2017, a multidisciplinary meeting of mesothelioma experts was cosponsored by the U.S. National Cancer Institute, International Association for the Study of Lung Cancer Research, and Mesothelioma Applied Research Foundation. Among the outcomes of this conference was the foundation of detailed, multidisciplinary consensus guidelines. RESULTS: Here we present consensus recommendations on the use of radiation therapy for MPM in three discrete scenarios: (1) hemithoracic radiation therapy to be used before or after extrapleural pneumonectomy; (2) hemithoracic radiation to be used as an adjuvant to lung-sparing procedures (i.e., without pneumonectomy); and (3) palliative radiation therapy for focal symptoms caused by the disease. We discuss appropriate simulation techniques, treatment volumes, dose fractionation regimens, and normal tissue constraints. We also assess the role of particle beam therapy, specifically, proton beam therapy, for MPM. CONCLUSION: The recommendations provided in this consensus statement should serve as important guidelines for developing future clinical trials of treatment approaches for MPM.

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Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

July 2019

Volume

14

Issue

7

Start / End Page

1172 / 1183

Location

United States

Related Subject Headings

  • United States
  • Thoracic Neoplasms
  • Radiotherapy
  • Pleural Neoplasms
  • Oncology & Carcinogenesis
  • National Cancer Institute (U.S.)
  • Mesothelioma, Malignant
  • Mesothelioma
  • Lung Neoplasms
  • International Agencies
 

Citation

APA
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MLA
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Gomez, D. R., Rimner, A., Simone, C. B., Cho, B. C. J., de Perrot, M., Adjei, A. A., … Rosenzweig, K. (2019). The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation. J Thorac Oncol, 14(7), 1172–1183. https://doi.org/10.1016/j.jtho.2019.03.030
Gomez, Daniel R., Andreas Rimner, Charles B. Simone, BC John Cho, Marc de Perrot, Alex A. Adjei, Raphael Bueno, et al. “The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation.J Thorac Oncol 14, no. 7 (July 2019): 1172–83. https://doi.org/10.1016/j.jtho.2019.03.030.
Gomez DR, Rimner A, Simone CB, Cho BCJ, de Perrot M, Adjei AA, Bueno R, Gill RR, Harpole DH, Hesdorffer M, Hirsch FR, Jackson AA, Pass HI, Rice DC, Rusch VW, Tsao AS, Yorke E, Rosenzweig K. The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation. J Thorac Oncol. 2019 Jul;14(7):1172–1183.
Journal cover image

Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

July 2019

Volume

14

Issue

7

Start / End Page

1172 / 1183

Location

United States

Related Subject Headings

  • United States
  • Thoracic Neoplasms
  • Radiotherapy
  • Pleural Neoplasms
  • Oncology & Carcinogenesis
  • National Cancer Institute (U.S.)
  • Mesothelioma, Malignant
  • Mesothelioma
  • Lung Neoplasms
  • International Agencies