Skip to main content
Journal cover image

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Publication ,  Journal Article
Yu, B; Zanetti, KA; Temprosa, M; Albanes, D; Appel, N; Barrera, CB; Ben-Shlomo, Y; Boerwinkle, E; Casas, JP; Clish, C; Dale, C; Dehghan, A ...
Published in: Am J Epidemiol
June 1, 2019

The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently used labs being Metabolon, Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants have been followed for a median of 23 years for health outcomes including death, cancer, cardiovascular disease, diabetes, and others; many of the studies are ongoing. Available exposure-related data include common clinical measurements and behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any 2 different laboratories ranged from 6 to 121 metabolites at 5 leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range, 0.56-0.89).

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 1, 2019

Volume

188

Issue

6

Start / End Page

991 / 1012

Location

United States

Related Subject Headings

  • Young Adult
  • Socioeconomic Factors
  • Prospective Studies
  • Middle Aged
  • Metabolomics
  • Male
  • Longitudinal Studies
  • Humans
  • Hematologic Tests
  • Health Behavior
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yu, B., Zanetti, K. A., Temprosa, M., Albanes, D., Appel, N., Barrera, C. B., … Moore, S. C. (2019). The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. Am J Epidemiol, 188(6), 991–1012. https://doi.org/10.1093/aje/kwz028
Yu, Bing, Krista A. Zanetti, Marinella Temprosa, Demetrius Albanes, Nathan Appel, Clara Barrios Barrera, Yoav Ben-Shlomo, et al. “The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.Am J Epidemiol 188, no. 6 (June 1, 2019): 991–1012. https://doi.org/10.1093/aje/kwz028.
Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, et al. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. Am J Epidemiol. 2019 Jun 1;188(6):991–1012.
Yu, Bing, et al. “The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.Am J Epidemiol, vol. 188, no. 6, June 2019, pp. 991–1012. Pubmed, doi:10.1093/aje/kwz028.
Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, Eliassen AH, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CM, Kivimäki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathé E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJ, Sesso HD, Shah SH, Shu X-O, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W, Moore SC. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. Am J Epidemiol. 2019 Jun 1;188(6):991–1012.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 1, 2019

Volume

188

Issue

6

Start / End Page

991 / 1012

Location

United States

Related Subject Headings

  • Young Adult
  • Socioeconomic Factors
  • Prospective Studies
  • Middle Aged
  • Metabolomics
  • Male
  • Longitudinal Studies
  • Humans
  • Hematologic Tests
  • Health Behavior