Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets.

Publication ,  Journal Article
Zhang, G; Colell, JFP; Glachet, T; Lindale, JR; Reboul, V; Theis, T; Warren, WS
Published in: Angewandte Chemie (International ed. in English)
August 2019

Diazirine moieties are chemically stable and have been incorporated into biomolecules without impediment of biological activity. The 15 N2 labeled diazirines are appealing motifs for hyperpolarization supporting relaxation protected states with long-lived lifetimes. The (-CH15 N2 ) diazirine groups investigated here are analogues to methyl groups, which provides the opportunity to transfer polarization stored on a relaxation protected (-CH15 N2 ) moiety to 1 H, thus combining the advantages of long lifetimes of 15 N polarization with superior sensitivity of 1 H detection. Despite the proximity of 1 H to 15 N nuclei in the diazirine moiety, 15 N T1 times of up to (4.6±0.4) min and singlet lifetimes Ts of up to (17.5±3.8) min are observed. Furthermore, we found terminal diazirines to support hyperpolarized 1 H2 singlet states in CH2 groups of chiral molecules. The singlet lifetime of 1 H singlets is up to (9.2±1.8) min, thus exceeding 1 H T1 relaxation time (at 8.45 T) by a factor of ≈100.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

August 2019

Volume

58

Issue

32

Start / End Page

11118 / 11124

Related Subject Headings

  • Organic Chemistry
  • Nitrogen Isotopes
  • Molecular Structure
  • Azirines
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, G., Colell, J. F. P., Glachet, T., Lindale, J. R., Reboul, V., Theis, T., & Warren, W. S. (2019). Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets. Angewandte Chemie (International Ed. in English), 58(32), 11118–11124. https://doi.org/10.1002/anie.201904026
Zhang, Guannan, Johannes F. P. Colell, Thomas Glachet, Jacob R. Lindale, Vincent Reboul, Thomas Theis, and Warren S. Warren. “Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets.Angewandte Chemie (International Ed. in English) 58, no. 32 (August 2019): 11118–24. https://doi.org/10.1002/anie.201904026.
Zhang G, Colell JFP, Glachet T, Lindale JR, Reboul V, Theis T, et al. Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets. Angewandte Chemie (International ed in English). 2019 Aug;58(32):11118–24.
Zhang, Guannan, et al. “Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets.Angewandte Chemie (International Ed. in English), vol. 58, no. 32, Aug. 2019, pp. 11118–24. Epmc, doi:10.1002/anie.201904026.
Zhang G, Colell JFP, Glachet T, Lindale JR, Reboul V, Theis T, Warren WS. Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets. Angewandte Chemie (International ed in English). 2019 Aug;58(32):11118–11124.
Journal cover image

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

August 2019

Volume

58

Issue

32

Start / End Page

11118 / 11124

Related Subject Headings

  • Organic Chemistry
  • Nitrogen Isotopes
  • Molecular Structure
  • Azirines
  • 34 Chemical sciences
  • 03 Chemical Sciences