Skip to main content

Collaborative Molecular Epidemiology Study of Metabolic Dysregulation, DNA Methylation, and Breast Cancer Risk Among Nigerian Women: MEND Study Objectives and Design.

Publication ,  Journal Article
Akinyemiju, T; Salako, O; Daramola, A; Alatise, O; Adeniyi, A; Ogun, G; Ayandipo, O; Olajide, T; Olasehinde, O; Arowolo, O; Adisa, A; Ojo, A ...
Published in: J Glob Oncol
June 2019

PURPOSE: To elucidate the role of metabolic dysregulation and associated DNA methylation changes on breast cancer risk and aggressive subtypes among Nigerian women. We describe the design and methods of a collaborative molecular epidemiology study of breast cancer in Nigerian hospitals. METHODS: The Mechanisms for Novel and Established Risk Factors for Breast Cancer in Women of Nigerian Descent (MEND) study was designed as a matched case-control study of 350 patients, age 18 to 75 years, with newly diagnosed, treatment-naïve breast cancer and 350 age-matched healthy controls from surrounding geographic areas. Patients with breast cancer seen for initial diagnosis at four large tertiary hospitals in southwest Nigeria and one affiliated private hospital were recruited. Healthy female controls were selected from a cohort of 4,000 healthy women recruited as part of the Human Heredity and Health (H3) in Africa Chronic Kidney Disease Case-Control Study in Nigeria. Tumor and adjacent normal tissue, and blood and saliva samples were collected for molecular and epigenetic assays. RESULTS: Although recruitment is ongoing, a total of 416 patients have been recruited to date, with tumor and blood samples obtained from at least 310 patients. Data on age-matched (± 6 months) controls have also been obtained and harmonized. Lipid assays for 350 pathologically verified cases and 350 age-matched controls is underway, and pathologic characterization of tumors (including immunohistochemistry for subtyping) is ongoing. Data on DNA methylation for tumors and adjacent normal tissue are expected by the end of the study period. CONCLUSION: The MEND study will provide a unique, high-quality source of data to evaluate the contribution of metabolic dysregulation such as obesity, diabetes, hypertension, and metabolic syndrome to the biology of breast cancer among Nigerian women and foster collaborative studies relevant for women of African descent globally.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Glob Oncol

DOI

EISSN

2378-9506

Publication Date

June 2019

Volume

5

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Research Design
  • Nigeria
  • Molecular Epidemiology
  • Middle Aged
  • Metabolic Diseases
  • Medical Records
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Akinyemiju, T., Salako, O., Daramola, A., Alatise, O., Adeniyi, A., Ogun, G., … Arnett, D. (2019). Collaborative Molecular Epidemiology Study of Metabolic Dysregulation, DNA Methylation, and Breast Cancer Risk Among Nigerian Women: MEND Study Objectives and Design. J Glob Oncol, 5, 1–9. https://doi.org/10.1200/JGO.18.00226
Akinyemiju, Tomi, Omolola Salako, Adetola Daramola, Olusegun Alatise, Adewale Adeniyi, Gabriel Ogun, Omobolaji Ayandipo, et al. “Collaborative Molecular Epidemiology Study of Metabolic Dysregulation, DNA Methylation, and Breast Cancer Risk Among Nigerian Women: MEND Study Objectives and Design.J Glob Oncol 5 (June 2019): 1–9. https://doi.org/10.1200/JGO.18.00226.
Akinyemiju T, Salako O, Daramola A, Alatise O, Adeniyi A, Ogun G, Ayandipo O, Olajide T, Olasehinde O, Arowolo O, Adisa A, Afuwape O, Olusanya A, Adegoke A, Ojo A, Tollefsbol T, Arnett D. Collaborative Molecular Epidemiology Study of Metabolic Dysregulation, DNA Methylation, and Breast Cancer Risk Among Nigerian Women: MEND Study Objectives and Design. J Glob Oncol. 2019 Jun;5:1–9.

Published In

J Glob Oncol

DOI

EISSN

2378-9506

Publication Date

June 2019

Volume

5

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Research Design
  • Nigeria
  • Molecular Epidemiology
  • Middle Aged
  • Metabolic Diseases
  • Medical Records
  • Humans
  • Female