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Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B.

Publication ,  Journal Article
Di Bisceglie, AM; King, WC; Lisker-Melman, M; Khalili, M; Belle, SH; Feld, JJ; Ghany, MG; Janssen, HLA; Lau, D; Lee, WM; Ling, SC; Cooper, S ...
Published in: J Viral Hepat
July 2019

Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viraemia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analysed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross-sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among those up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; the prevalence of HBeAg was significantly higher among Asians > 10-30 years old vs Whites or Blacks who were >10 to 30 years old and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and precore variants was associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy.

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Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

July 2019

Volume

26

Issue

7

Start / End Page

856 / 865

Location

England

Related Subject Headings

  • Young Adult
  • Viral Load
  • Seroepidemiologic Studies
  • Public Health Surveillance
  • Population Groups
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Hepatitis B, Chronic
 

Citation

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Di Bisceglie, A. M., King, W. C., Lisker-Melman, M., Khalili, M., Belle, S. H., Feld, J. J., … Hepatitis B Research Network (HBRN). (2019). Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. J Viral Hepat, 26(7), 856–865. https://doi.org/10.1111/jvh.13104
Di Bisceglie, Adrian M., Wendy C. King, Mauricio Lisker-Melman, Mandana Khalili, Steven H. Belle, Jordan J. Feld, Marc G. Ghany, et al. “Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B.J Viral Hepat 26, no. 7 (July 2019): 856–65. https://doi.org/10.1111/jvh.13104.
Di Bisceglie AM, King WC, Lisker-Melman M, Khalili M, Belle SH, Feld JJ, et al. Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. J Viral Hepat. 2019 Jul;26(7):856–65.
Di Bisceglie, Adrian M., et al. “Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B.J Viral Hepat, vol. 26, no. 7, July 2019, pp. 856–65. Pubmed, doi:10.1111/jvh.13104.
Di Bisceglie AM, King WC, Lisker-Melman M, Khalili M, Belle SH, Feld JJ, Ghany MG, Janssen HLA, Lau D, Lee WM, Ling SC, Cooper S, Rosenthal P, Schwarz KB, Sterling RK, Teckman JH, Terrault N, Hepatitis B Research Network (HBRN). Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B. J Viral Hepat. 2019 Jul;26(7):856–865.
Journal cover image

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

July 2019

Volume

26

Issue

7

Start / End Page

856 / 865

Location

England

Related Subject Headings

  • Young Adult
  • Viral Load
  • Seroepidemiologic Studies
  • Public Health Surveillance
  • Population Groups
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Hepatitis B, Chronic