Skip to main content

Conduct disorder.

Publication ,  Journal Article
Fairchild, G; Hawes, DJ; Frick, PJ; Copeland, WE; Odgers, CL; Franke, B; Freitag, CM; De Brito, SA
Published in: Nat Rev Dis Primers
June 27, 2019

Conduct disorder (CD) is a common and highly impairing psychiatric disorder that usually emerges in childhood or adolescence and is characterized by severe antisocial and aggressive behaviour. It frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD) and often leads to antisocial personality disorder in adulthood. CD affects ~3% of school-aged children and is twice as prevalent in males than in females. This disorder can be subtyped according to age at onset (childhood-onset versus adolescent-onset) and the presence or absence of callous-unemotional traits (deficits in empathy and guilt). The aetiology of CD is complex, with contributions of both genetic and environmental risk factors and different forms of interplay among the two (gene-environment interaction and correlation). In addition, CD is associated with neurocognitive impairments; smaller grey matter volume in limbic regions such as the amygdala, insula and orbitofrontal cortex, and functional abnormalities in overlapping brain circuits responsible for emotion processing, emotion regulation and reinforcement-based decision-making have been reported. Lower hypothalamic-pituitary-adrenal axis and autonomic reactivity to stress has also been reported. Management of CD primarily involves parent-based or family-based psychosocial interventions, although stimulants and atypical antipsychotics are sometimes used, especially in individuals with comorbid ADHD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Dis Primers

DOI

EISSN

2056-676X

Publication Date

June 27, 2019

Volume

5

Issue

1

Start / End Page

43

Location

England

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Mental Disorders
  • Mass Screening
  • Male
  • Humans
  • Genetic Diseases, Inborn
  • Functional Neuroimaging
  • Female
  • Conduct Disorder
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fairchild, G., Hawes, D. J., Frick, P. J., Copeland, W. E., Odgers, C. L., Franke, B., … De Brito, S. A. (2019). Conduct disorder. Nat Rev Dis Primers, 5(1), 43. https://doi.org/10.1038/s41572-019-0095-y
Fairchild, Graeme, David J. Hawes, Paul J. Frick, William E. Copeland, Candice L. Odgers, Barbara Franke, Christine M. Freitag, and Stephane A. De Brito. “Conduct disorder.Nat Rev Dis Primers 5, no. 1 (June 27, 2019): 43. https://doi.org/10.1038/s41572-019-0095-y.
Fairchild G, Hawes DJ, Frick PJ, Copeland WE, Odgers CL, Franke B, et al. Conduct disorder. Nat Rev Dis Primers. 2019 Jun 27;5(1):43.
Fairchild, Graeme, et al. “Conduct disorder.Nat Rev Dis Primers, vol. 5, no. 1, June 2019, p. 43. Pubmed, doi:10.1038/s41572-019-0095-y.
Fairchild G, Hawes DJ, Frick PJ, Copeland WE, Odgers CL, Franke B, Freitag CM, De Brito SA. Conduct disorder. Nat Rev Dis Primers. 2019 Jun 27;5(1):43.

Published In

Nat Rev Dis Primers

DOI

EISSN

2056-676X

Publication Date

June 27, 2019

Volume

5

Issue

1

Start / End Page

43

Location

England

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Mental Disorders
  • Mass Screening
  • Male
  • Humans
  • Genetic Diseases, Inborn
  • Functional Neuroimaging
  • Female
  • Conduct Disorder