Developmental pharmacogenomics.
Publication
, Journal Article
Neville, KA; Becker, ML; Goldman, JL; Kearns, GL
Published in: Paediatr Anaesth
March 2011
Interindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Genotype-phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and pharmacodynamics. This review explores pharmacogenomics in the context of ontogeny and relates these to the expression of drug-metabolizing enzymes and transporters and the consequent effect on the exposure-response relationship in the early years of life.
Duke Scholars
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Published In
Paediatr Anaesth
DOI
EISSN
1460-9592
Publication Date
March 2011
Volume
21
Issue
3
Start / End Page
255 / 265
Location
France
Related Subject Headings
- Pharmacogenetics
- Pharmaceutical Preparations
- Infant
- Humans
- Enzymes
- Drug Therapy
- Cytochrome P-450 Enzyme System
- Clinical Trials as Topic
- Child, Preschool
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Neville, K. A., Becker, M. L., Goldman, J. L., & Kearns, G. L. (2011). Developmental pharmacogenomics. Paediatr Anaesth, 21(3), 255–265. https://doi.org/10.1111/j.1460-9592.2011.03533.x
Neville, Kathleen A., Mara L. Becker, Jennifer L. Goldman, and Gregory L. Kearns. “Developmental pharmacogenomics.” Paediatr Anaesth 21, no. 3 (March 2011): 255–65. https://doi.org/10.1111/j.1460-9592.2011.03533.x.
Neville KA, Becker ML, Goldman JL, Kearns GL. Developmental pharmacogenomics. Paediatr Anaesth. 2011 Mar;21(3):255–65.
Neville, Kathleen A., et al. “Developmental pharmacogenomics.” Paediatr Anaesth, vol. 21, no. 3, Mar. 2011, pp. 255–65. Pubmed, doi:10.1111/j.1460-9592.2011.03533.x.
Neville KA, Becker ML, Goldman JL, Kearns GL. Developmental pharmacogenomics. Paediatr Anaesth. 2011 Mar;21(3):255–265.
Published In
Paediatr Anaesth
DOI
EISSN
1460-9592
Publication Date
March 2011
Volume
21
Issue
3
Start / End Page
255 / 265
Location
France
Related Subject Headings
- Pharmacogenetics
- Pharmaceutical Preparations
- Infant
- Humans
- Enzymes
- Drug Therapy
- Cytochrome P-450 Enzyme System
- Clinical Trials as Topic
- Child, Preschool
- Child