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Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study.

Publication ,  Journal Article
Forestieri, NE; Desrosiers, TA; Freedman, SF; Aylsworth, AS; Voltzke, K; Olshan, AF; Meyer, RE; National Birth Defects Prevention Study,
Published in: Am J Med Genet A
September 2019

Primary congenital glaucoma (PCG) is a rare but serious birth defect. Genetic mutations have been implicated in the development of PCG, but little is known about nongenetic risk factors. This study investigates potential risk factors for PCG in the National Birth Defects Prevention Study (NBDPS), a large population-based case-control study of major birth defects in the United States. The analysis includes case infants with PCG (N = 107) and control infants without birth defects (N = 10,084) enrolled in NBDPS from birth years 2000-2011. Pregnancy/infant clinical characteristics, demographics, and parental health history were collected through maternal interview. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were computed to examine associations with all PCG cases and isolated PCG cases without other major malformations. Associations with all the cases included term low birth weight (<2,500 g; aOR = 2.80, CI 1.59-4.94), non-Hispanic black maternal race/ethnicity (aOR = 2.42, CI 1.42-4.13), maternal history of seizure (aOR = 2.73, CI 1.25-5.97), maternal antihypertensive use (aOR = 3.60, CI 1.52-8.53), and maternal sexually transmitted infection (aOR = 2.75, CI 1.17-6.44). These factors were also associated with isolated PCG, as was maternal use of nonsteroidal anti-inflammatory drugs (aOR = 2.70, CI 1.15-6.34). This study is among the first to examine a wide array of potential risk factors for PCG in a population-based sample.

Duke Scholars

Published In

Am J Med Genet A

DOI

EISSN

1552-4833

Publication Date

September 2019

Volume

179

Issue

9

Start / End Page

1846 / 1856

Location

United States

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • Population
  • Mutation
  • Maternal Age
  • Male
  • Logistic Models
  • Infant
  • Humans
  • Glaucoma
 

Citation

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ICMJE
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Forestieri, N. E., Desrosiers, T. A., Freedman, S. F., Aylsworth, A. S., Voltzke, K., Olshan, A. F., … National Birth Defects Prevention Study, . (2019). Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study. Am J Med Genet A, 179(9), 1846–1856. https://doi.org/10.1002/ajmg.a.61296
Forestieri, Nina E., Tania A. Desrosiers, Sharon F. Freedman, Arthur S. Aylsworth, Kristin Voltzke, Andrew F. Olshan, Robert E. Meyer, and Robert E. National Birth Defects Prevention Study. “Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study.Am J Med Genet A 179, no. 9 (September 2019): 1846–56. https://doi.org/10.1002/ajmg.a.61296.
Forestieri NE, Desrosiers TA, Freedman SF, Aylsworth AS, Voltzke K, Olshan AF, et al. Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study. Am J Med Genet A. 2019 Sep;179(9):1846–56.
Forestieri, Nina E., et al. “Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study.Am J Med Genet A, vol. 179, no. 9, Sept. 2019, pp. 1846–56. Pubmed, doi:10.1002/ajmg.a.61296.
Forestieri NE, Desrosiers TA, Freedman SF, Aylsworth AS, Voltzke K, Olshan AF, Meyer RE, National Birth Defects Prevention Study. Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study. Am J Med Genet A. 2019 Sep;179(9):1846–1856.
Journal cover image

Published In

Am J Med Genet A

DOI

EISSN

1552-4833

Publication Date

September 2019

Volume

179

Issue

9

Start / End Page

1846 / 1856

Location

United States

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • Population
  • Mutation
  • Maternal Age
  • Male
  • Logistic Models
  • Infant
  • Humans
  • Glaucoma