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The role of π-helices in TRP channel gating.
Publication
, Journal Article
Zubcevic, L; Lee, S-Y
Published in: Curr Opin Struct Biol
October 2019
Transient Receptor Potential (TRP) channels are a large superfamily of polymodal ion channels, which perform important roles in numerous physiological processes. The architecture of their transmembrane (TM) domains closely resembles that of voltage-gated potassium channels (KV). However, recent cryoEM and crystallographic studies of TRP channels have identified π-helices in functionally important regions, and it is increasingly recognized that they utilize a distinct mechanism of gating that relies on α-to-π secondary structure transitions. Here we review our current understanding of the role of π-helices in TRP channel function and their broader impact on different classes of ion channels.
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Published In
Curr Opin Struct Biol
DOI
EISSN
1879-033X
Publication Date
October 2019
Volume
58
Start / End Page
314 / 323
Location
England
Related Subject Headings
- TRPC Cation Channels
- Protein Conformation, alpha-Helical
- Ion Channel Gating
- Humans
- Conserved Sequence
- Biophysics
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Zubcevic, L., & Lee, S.-Y. (2019). The role of π-helices in TRP channel gating. Curr Opin Struct Biol, 58, 314–323. https://doi.org/10.1016/j.sbi.2019.06.011
Zubcevic, Lejla, and Seok-Yong Lee. “The role of π-helices in TRP channel gating.” Curr Opin Struct Biol 58 (October 2019): 314–23. https://doi.org/10.1016/j.sbi.2019.06.011.
Zubcevic L, Lee S-Y. The role of π-helices in TRP channel gating. Curr Opin Struct Biol. 2019 Oct;58:314–23.
Zubcevic, Lejla, and Seok-Yong Lee. “The role of π-helices in TRP channel gating.” Curr Opin Struct Biol, vol. 58, Oct. 2019, pp. 314–23. Pubmed, doi:10.1016/j.sbi.2019.06.011.
Zubcevic L, Lee S-Y. The role of π-helices in TRP channel gating. Curr Opin Struct Biol. 2019 Oct;58:314–323.
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1879-033X&client=dukeuniv)
Published In
Curr Opin Struct Biol
DOI
EISSN
1879-033X
Publication Date
October 2019
Volume
58
Start / End Page
314 / 323
Location
England
Related Subject Headings
- TRPC Cation Channels
- Protein Conformation, alpha-Helical
- Ion Channel Gating
- Humans
- Conserved Sequence
- Biophysics
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry