Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation.

Publication ,  Journal Article
Choi, J-I; Baek, YS; Roh, SY; Piccini, JP; Kim, Y-H
Published in: J Cardiovasc Electrophysiol
October 2019

INTRODUCTION: Little is known about how genetic predisposition and fibrosis relate in atrial fibrillation (AF). Hence, we sought to determine whether the genetic variants and biomarkers for fibrosis enhance prediction of outcomes after catheter ablation. METHODS AND RESULTS: Consecutive patients who underwent catheter ablation of AF (paroxysmal, 158; nonparoxysmal, 137) or supraventricular tachycardia without AF (n = 70) were studied retrospectively. Plasma levels of transforming growth factor β1 (TGF-β1), tissue inhibitor of metalloproteinase 1 (TIMP-1), and 4q25 single-nucleotide polymorphisms (SNPs) (rs10033464 and rs220073) were measured. Mean plasma levels of both TGF-β1 and TIMP-1 were higher in patients with AF than in the control (all P < .001). Plasma levels of TIMP-1 were higher in patients with recurrence compared with those without recurrence (P = .039). Patients with variant alleles of rs10033464 showed increased recurrence after catheter ablation in patients with paroxysmal AF including after adjustment (P = .027). Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. Inclusion of biomarkers and genotype improved discrimination of AF recurrence in patients with paroxysmal AF (C-statistic .499 vs .600). CONCLUSIONS: The combination of plasma TIMP-1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. This study suggests that 4q25 SNPs and biomarkers for fibrosis may provide additive value in risk stratification for AF recurrence after catheter ablation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2019

Volume

30

Issue

10

Start / End Page

1904 / 1913

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Transforming Growth Factor beta1
  • Tissue Inhibitor of Metalloproteinase-1
  • Time Factors
  • Tachycardia, Supraventricular
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Choi, J.-I., Baek, Y. S., Roh, S. Y., Piccini, J. P., & Kim, Y.-H. (2019). Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation. J Cardiovasc Electrophysiol, 30(10), 1904–1913. https://doi.org/10.1111/jce.14104
Choi, Jong-Il, Yong Soo Baek, Seung Young Roh, Jonathan P. Piccini, and Young-Hoon Kim. “Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation.J Cardiovasc Electrophysiol 30, no. 10 (October 2019): 1904–13. https://doi.org/10.1111/jce.14104.
Choi J-I, Baek YS, Roh SY, Piccini JP, Kim Y-H. Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2019 Oct;30(10):1904–13.
Choi, Jong-Il, et al. “Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation.J Cardiovasc Electrophysiol, vol. 30, no. 10, Oct. 2019, pp. 1904–13. Pubmed, doi:10.1111/jce.14104.
Choi J-I, Baek YS, Roh SY, Piccini JP, Kim Y-H. Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2019 Oct;30(10):1904–1913.
Journal cover image

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2019

Volume

30

Issue

10

Start / End Page

1904 / 1913

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Transforming Growth Factor beta1
  • Tissue Inhibitor of Metalloproteinase-1
  • Time Factors
  • Tachycardia, Supraventricular
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries