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Renal Effects of Cytokines in Hypertension.

Publication ,  Journal Article
Wen, Y; Crowley, SD
Published in: Adv Exp Med Biol
2019

Preclinical studies point to a key role for immune cells in hypertension via augmenting renal injury and/or hypertensive responses. Blood pressure elevation in rheumatologic patients is attenuated by anti-inflammatory therapies. Both the innate and adaptive immune systems contribute to the pathogenesis of hypertension by modulating renal sodium balance, blood flow, and functions of the vasculature and epithelial cells in the kidney. Monocytes/macrophages and T lymphocytes are pivotal mediators of hypertensive responses, while dendritic cells and B lymphocytes can regulate blood pressure indirectly by promoting T lymphocytes activation. Pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF), interleukin-1 (IL-1), interleukin-17 (IL-17), and interferon-γ (IFN), amplify blood pressure elevation and/or renal injury. By contrast, interleukin-10 (IL-10) protects against renal and vascular function when produced by T helper 2 cells (Th2) and regulatory T cells (Treg). Thus, understanding the renal effects of cytokines in hypertension will provide targets for precise immunotherapies to inhibit targeted organ damage while preserving necessary immunity.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2019

Volume

1165

Start / End Page

443 / 454

Location

United States

Related Subject Headings

  • Th2 Cells
  • T-Lymphocytes, Regulatory
  • Lymphocyte Activation
  • Kidney
  • Hypertension
  • Humans
  • General & Internal Medicine
  • Cytokines
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

APA
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Wen, Y., & Crowley, S. D. (2019). Renal Effects of Cytokines in Hypertension. Adv Exp Med Biol, 1165, 443–454. https://doi.org/10.1007/978-981-13-8871-2_21
Wen, Yi, and Steven D. Crowley. “Renal Effects of Cytokines in Hypertension.Adv Exp Med Biol 1165 (2019): 443–54. https://doi.org/10.1007/978-981-13-8871-2_21.
Wen Y, Crowley SD. Renal Effects of Cytokines in Hypertension. Adv Exp Med Biol. 2019;1165:443–54.
Wen, Yi, and Steven D. Crowley. “Renal Effects of Cytokines in Hypertension.Adv Exp Med Biol, vol. 1165, 2019, pp. 443–54. Pubmed, doi:10.1007/978-981-13-8871-2_21.
Wen Y, Crowley SD. Renal Effects of Cytokines in Hypertension. Adv Exp Med Biol. 2019;1165:443–454.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2019

Volume

1165

Start / End Page

443 / 454

Location

United States

Related Subject Headings

  • Th2 Cells
  • T-Lymphocytes, Regulatory
  • Lymphocyte Activation
  • Kidney
  • Hypertension
  • Humans
  • General & Internal Medicine
  • Cytokines
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences