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Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.

Publication ,  Journal Article
Villafuerte, D; Aliberti, S; Soni, NJ; Faverio, P; Marcos, PJ; Wunderink, RG; Rodriguez, A; Sibila, O; Sanz, F; Martin-Loeches, I; Menzella, F ...
Published in: Respirology
May 2020

BACKGROUND AND OBJECTIVE: Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community-acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. METHODS: We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when ≥3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. RESULTS: Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. CONCLUSION: This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP.

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Published In

Respirology

DOI

EISSN

1440-1843

Publication Date

May 2020

Volume

25

Issue

5

Start / End Page

543 / 551

Location

Australia

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Prevalence
  • Microbial Sensitivity Tests
  • Male
  • International Cooperation
  • Humans
  • Hospitalization
  • Female
  • Enterobacteriaceae Infections
 

Citation

APA
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MLA
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Villafuerte, D., Aliberti, S., Soni, N. J., Faverio, P., Marcos, P. J., Wunderink, R. G., … GLIMP Investigators, . (2020). Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. Respirology, 25(5), 543–551. https://doi.org/10.1111/resp.13663
Villafuerte, David, Stefano Aliberti, Nilam J. Soni, Paola Faverio, Pedro J. Marcos, Richard G. Wunderink, Alejandro Rodriguez, et al. “Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.Respirology 25, no. 5 (May 2020): 543–51. https://doi.org/10.1111/resp.13663.
Villafuerte D, Aliberti S, Soni NJ, Faverio P, Marcos PJ, Wunderink RG, et al. Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. Respirology. 2020 May;25(5):543–51.
Villafuerte, David, et al. “Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.Respirology, vol. 25, no. 5, May 2020, pp. 543–51. Pubmed, doi:10.1111/resp.13663.
Villafuerte D, Aliberti S, Soni NJ, Faverio P, Marcos PJ, Wunderink RG, Rodriguez A, Sibila O, Sanz F, Martin-Loeches I, Menzella F, Reyes LF, Jankovic M, Spielmanns M, Restrepo MI, GLIMP Investigators. Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia. Respirology. 2020 May;25(5):543–551.
Journal cover image

Published In

Respirology

DOI

EISSN

1440-1843

Publication Date

May 2020

Volume

25

Issue

5

Start / End Page

543 / 551

Location

Australia

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Prevalence
  • Microbial Sensitivity Tests
  • Male
  • International Cooperation
  • Humans
  • Hospitalization
  • Female
  • Enterobacteriaceae Infections