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Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations.

Publication ,  Journal Article
Visco, C; Wang, J; Tisi, MC; Deng, L; D'Amore, ESG; Tzankov, A; Montes-Moreno, S; Dybkær, K; Bhagat, G; Hsi, ED; van Krieken, JH; Ponzoni, M ...
Published in: Br J Cancer
November 21, 2017

BACKGROUND: The clinical presentation of patients with hepatitis C virus (HCV)-positive diffuse large B-cell lymphoma (DLBCL) is different from their HCV-negative counterparts, but the underlying molecular and pathological characteristics are largely under investigated. The virus has a role in lymphomagenesis, as witnessed by the curative potential of antiviral therapy in HCV-related low-grade B-cell lymphomas. METHODS: We performed a case-control study including 44 HCV-positive cases of de novo DLBCL, comparing them with 132 HCV-negative patients as controls (ratio 3 to 1). Cases and controls were matched for age, lactate dehydrogenase level and international prognostic index at presentation. Patients were studied by gene expression profiling for cell-of-origin determination and to perform differential expression analysis between groups, fluorescence in-situ hybridisation and immunohistochemistry for MYC, BCL2 and BCL6, TP53 mutations, and diagnostic specimens reviewed to exclude transformation from low-grade lymphoma. RESULTS: Compared to the HCV-negative controls, patients with HCV-positive de novo DLBCL had differential expression of genes that regulate innate immune response and modulate apoptotic pathways, have higher proliferative index, and lack BCL2 translocations. CONCLUSIONS: HCV-positive DLBCL have distinct molecular and pathological features compared to the HCV-negative counterparts.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

November 21, 2017

Volume

117

Issue

11

Start / End Page

1685 / 1688

Location

England

Related Subject Headings

  • Translocation, Genetic
  • Proto-Oncogene Proteins c-bcl-6
  • Proto-Oncogene Proteins c-bcl-2
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Hepacivirus
  • Genes, myc
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Visco, C., Wang, J., Tisi, M. C., Deng, L., D’Amore, E. S. G., Tzankov, A., … Young, K. H. (2017). Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. Br J Cancer, 117(11), 1685–1688. https://doi.org/10.1038/bjc.2017.345
Visco, Carlo, Jinfen Wang, Maria Chiara Tisi, Lijuan Deng, Emanuele S. G. D’Amore, Alexandar Tzankov, Santiago Montes-Moreno, et al. “Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations.Br J Cancer 117, no. 11 (November 21, 2017): 1685–88. https://doi.org/10.1038/bjc.2017.345.
Visco C, Wang J, Tisi MC, Deng L, D’Amore ESG, Tzankov A, et al. Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. Br J Cancer. 2017 Nov 21;117(11):1685–8.
Visco, Carlo, et al. “Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations.Br J Cancer, vol. 117, no. 11, Nov. 2017, pp. 1685–88. Pubmed, doi:10.1038/bjc.2017.345.
Visco C, Wang J, Tisi MC, Deng L, D’Amore ESG, Tzankov A, Montes-Moreno S, Dybkær K, Bhagat G, Hsi ED, van Krieken JH, Ponzoni M, Ferreri AJM, Møller MB, Piris MA, Medeiros LJ, Xu-Monette ZY, Young KH. Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. Br J Cancer. 2017 Nov 21;117(11):1685–1688.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

November 21, 2017

Volume

117

Issue

11

Start / End Page

1685 / 1688

Location

England

Related Subject Headings

  • Translocation, Genetic
  • Proto-Oncogene Proteins c-bcl-6
  • Proto-Oncogene Proteins c-bcl-2
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Hepacivirus
  • Genes, myc