Scholars@Duke publication: Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.

Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.

Publication , Journal Article

Wang, S; Tzankov, A; Xu-Monette, ZY; Hoeller, S; Wang, SA; Richards, KL; Zhang, S; Said, JW; Medeiros, LJ; Young, KH

Published in: Hum Pathol

December 2013

Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.

Duke Scholars

Author Zijun Yidan Xu-Monette Pathology

Author Ken H Young Pathology

Published In

Hum Pathol

DOI

10.1016/j.humpath.2013.07.007

EISSN

1532-8392

Publication Date

December 2013

Volume

Issue

Start / End Page

2658 / 2667

Location

United States

Related Subject Headings

Pathology
Male
Lymphoma, Mantle-Cell
Lymphoma, Follicular
Lymph Nodes
Immunoglobulin Heavy Chains
Humans
Female
Cyclin D1
Composite Lymphoma

Citation

APA

Chicago

ICMJE

MLA

NLM

Wang, S., Tzankov, A., Xu-Monette, Z. Y., Hoeller, S., Wang, S. A., Richards, K. L., … Young, K. H. (2013). Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Hum Pathol, 44(12), 2658–2667. https://doi.org/10.1016/j.humpath.2013.07.007

Wang, Shi, Alexander Tzankov, Zijun Y. Xu-Monette, Sylvia Hoeller, Sa A. Wang, Kristy L. Richards, Shanxiang Zhang, Jonathan W. Said, L Jeffrey Medeiros, and Ken H. Young. “Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.” Hum Pathol 44, no. 12 (December 2013): 2658–67. https://doi.org/10.1016/j.humpath.2013.07.007.

Wang S, Tzankov A, Xu-Monette ZY, Hoeller S, Wang SA, Richards KL, et al. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Hum Pathol. 2013 Dec;44(12):2658–67.

Wang, Shi, et al. “Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.” Hum Pathol, vol. 44, no. 12, Dec. 2013, pp. 2658–67. Pubmed, doi:10.1016/j.humpath.2013.07.007.

Wang S, Tzankov A, Xu-Monette ZY, Hoeller S, Wang SA, Richards KL, Zhang S, Said JW, Medeiros LJ, Young KH. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Hum Pathol. 2013 Dec;44(12):2658–2667.