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Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.

Publication ,  Journal Article
Hoeller, S; Zhou, Y; Kanagal-Shamanna, R; Xu-Monette, ZY; Hoehn, D; Bihl, M; Swerdlow, SH; Rosenwald, A; Ott, G; Said, J; Dunphy, CH; Lin, P ...
Published in: Hum Pathol
January 2013

Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) share many features and both arise from CD5+ B-cells; their distinction is critical as MCL is a more aggressive neoplasm. Rarely, cases of composite MCL and CLL/SLL have been reported. Little is known about the nature of these cases and, in particular, the clonal relationship of the 2 lymphomas. Eleven composite MCL and CLL/SLL cases were identified. The clinical, morphologic and immunophenotypic features of the MCL and CLL/SLL were characterized. IGH (immunoglobulin heavy chain) gene analysis was performed on microdissected MCL and CLL/SLL components to assess their clonal relationship. Ten patients had lymphadenopathy, and 7 patients had bone marrow involvement. The MCL component had the following growth patterns: in situ (n = 1), mantle zone (n = 3), nodular and diffuse (n = 3), diffuse (n = 3), and interstitial in the bone marrow (the only patient without lymphadenopathy) (n = 1); 6 MCLs had blastoid or pleomorphic and 5 small lymphocytic features. The CLL/SLL component was nodular (n = 9) or diffuse (n = 2). All MCL were CD5(+) and cyclin D1(+) with t(11;14) translocation. All CLL/SLL were CD5(+), CD23(+) and negative for cyclin D1 or t(11;14). IGH gene analysis showed that the MCL and CLL/SLL components displayed different sized fragments, indicating that the MCL and CLL/SLL are likely derived from different neoplastic B-cell clones. The lack of a clonal relationship between the MCL and CLL/SLL components suggests that MCL and CLL/SLL components represent distinct disease processes and do not share a common progenitor B-cell.

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Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

January 2013

Volume

44

Issue

1

Start / End Page

110 / 121

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunophenotyping
  • Immunoglobulin Heavy Chains
  • Humans
  • Gene Rearrangement, B-Lymphocyte
  • Female
 

Citation

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Hoeller, S., Zhou, Y., Kanagal-Shamanna, R., Xu-Monette, Z. Y., Hoehn, D., Bihl, M., … Young, K. H. (2013). Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol, 44(1), 110–121. https://doi.org/10.1016/j.humpath.2012.04.022
Hoeller, Sylvia, Yi Zhou, Rashmi Kanagal-Shamanna, Zijun Y. Xu-Monette, Daniela Hoehn, Michel Bihl, Steven H. Swerdlow, et al. “Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.Hum Pathol 44, no. 1 (January 2013): 110–21. https://doi.org/10.1016/j.humpath.2012.04.022.
Hoeller S, Zhou Y, Kanagal-Shamanna R, Xu-Monette ZY, Hoehn D, Bihl M, et al. Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol. 2013 Jan;44(1):110–21.
Hoeller, Sylvia, et al. “Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.Hum Pathol, vol. 44, no. 1, Jan. 2013, pp. 110–21. Pubmed, doi:10.1016/j.humpath.2012.04.022.
Hoeller S, Zhou Y, Kanagal-Shamanna R, Xu-Monette ZY, Hoehn D, Bihl M, Swerdlow SH, Rosenwald A, Ott G, Said J, Dunphy CH, Bueso-Ramos CE, Lin P, Wang M, Miranda RN, Tzankov A, Medeiros LJ, Young KH. Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study. Hum Pathol. 2013 Jan;44(1):110–121.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

January 2013

Volume

44

Issue

1

Start / End Page

110 / 121

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Mantle-Cell
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunophenotyping
  • Immunoglobulin Heavy Chains
  • Humans
  • Gene Rearrangement, B-Lymphocyte
  • Female