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Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?

Publication ,  Journal Article
Lester, A; Rapkins, R; Nixdorf, S; Khasraw, M; McDonald, K
Published in: Clin Transl Oncol
March 2017

Glioblastoma (GBM) is fatal. The standard radiotherapy and chemotherapy (temozolomide) followed by an adjuvant phase of temozolomide provide patients with, on average, a 2.5 months benefit. New treatments that can improve sensitivity to the standard treatment are urgently needed. Herein, we review the mechanisms and utility of poly (ADP-ribose) polymerase inhibitors in combination with radiation therapy as a treatment option for GBM patients and the role of phosphatase and tensin homologue mutations as a biomarker of response.

Duke Scholars

Published In

Clin Transl Oncol

DOI

EISSN

1699-3055

Publication Date

March 2017

Volume

19

Issue

3

Start / End Page

273 / 278

Location

Italy

Related Subject Headings

  • Prognosis
  • Poly(ADP-ribose) Polymerase Inhibitors
  • PTEN Phosphohydrolase
  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Glioblastoma
  • Chemoradiotherapy
  • Brain Neoplasms
  • Biomarkers, Tumor
 

Citation

APA
Chicago
ICMJE
MLA
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Lester, A., Rapkins, R., Nixdorf, S., Khasraw, M., & McDonald, K. (2017). Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response? Clin Transl Oncol, 19(3), 273–278. https://doi.org/10.1007/s12094-016-1547-4
Lester, A., R. Rapkins, S. Nixdorf, M. Khasraw, and K. McDonald. “Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?Clin Transl Oncol 19, no. 3 (March 2017): 273–78. https://doi.org/10.1007/s12094-016-1547-4.
Lester A, Rapkins R, Nixdorf S, Khasraw M, McDonald K. Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response? Clin Transl Oncol. 2017 Mar;19(3):273–8.
Lester, A., et al. “Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?Clin Transl Oncol, vol. 19, no. 3, Mar. 2017, pp. 273–78. Pubmed, doi:10.1007/s12094-016-1547-4.
Lester A, Rapkins R, Nixdorf S, Khasraw M, McDonald K. Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response? Clin Transl Oncol. 2017 Mar;19(3):273–278.
Journal cover image

Published In

Clin Transl Oncol

DOI

EISSN

1699-3055

Publication Date

March 2017

Volume

19

Issue

3

Start / End Page

273 / 278

Location

Italy

Related Subject Headings

  • Prognosis
  • Poly(ADP-ribose) Polymerase Inhibitors
  • PTEN Phosphohydrolase
  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Glioblastoma
  • Chemoradiotherapy
  • Brain Neoplasms
  • Biomarkers, Tumor