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Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.

Publication ,  Journal Article
Meluzzi, D; Arya, G
Published in: Methods (San Diego, Calif.)
October 2020

Chromosome conformation capture (3C) and its variants are powerful experimental techniques for probing intra- and inter-chromosomal interactions within cell nuclei at high resolution and in a high-throughput, quantitative manner. The contact maps derived from such experiments provide an avenue for inferring the 3D spatial organization of the genome. This review provides an overview of the various computational methods developed in the past decade for addressing the very important but challenging problem of deducing the detailed 3D structure or structure population of chromosomal domains, chromosomes, and even entire genomes from 3C contact maps.

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Published In

Methods (San Diego, Calif.)

DOI

EISSN

1095-9130

ISSN

1046-2023

Publication Date

October 2020

Volume

181-182

Start / End Page

24 / 34

Related Subject Headings

  • Protein Structure, Tertiary
  • Nucleic Acid Conformation
  • Humans
  • Histones
  • High-Throughput Nucleotide Sequencing
  • Genomics
  • DNA
  • Chromosomes
  • Chromosome Mapping
  • Chromatin
 

Citation

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Meluzzi, D., & Arya, G. (2020). Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. Methods (San Diego, Calif.), 181182, 24–34. https://doi.org/10.1016/j.ymeth.2019.08.008
Meluzzi, Dario, and Gaurav Arya. “Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.Methods (San Diego, Calif.) 181–182 (October 2020): 24–34. https://doi.org/10.1016/j.ymeth.2019.08.008.
Meluzzi D, Arya G. Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. Methods (San Diego, Calif). 2020 Oct;181–182:24–34.
Meluzzi, Dario, and Gaurav Arya. “Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.Methods (San Diego, Calif.), vol. 181–182, Oct. 2020, pp. 24–34. Epmc, doi:10.1016/j.ymeth.2019.08.008.
Meluzzi D, Arya G. Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. Methods (San Diego, Calif). 2020 Oct;181–182:24–34.
Journal cover image

Published In

Methods (San Diego, Calif.)

DOI

EISSN

1095-9130

ISSN

1046-2023

Publication Date

October 2020

Volume

181-182

Start / End Page

24 / 34

Related Subject Headings

  • Protein Structure, Tertiary
  • Nucleic Acid Conformation
  • Humans
  • Histones
  • High-Throughput Nucleotide Sequencing
  • Genomics
  • DNA
  • Chromosomes
  • Chromosome Mapping
  • Chromatin