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Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels

Publication ,  Journal Article
Dilla, RA; Motta, CMM; Snyder, SR; Wilson, JA; Wesdemiotis, C; Becker, ML
Published in: ACS Macro Letters
October 16, 2018

PEG-based hydrogels are used widely in exploratory tissue engineering applications but in general lack chemical and structural diversity. Additive manufacturing offers pathways to otherwise unattainable scaffold morphologies but has been applied sparingly to cross-linked hydrogels. Herein, monomethyl ether poly(ethylene glycol) (PEG) and PEG-diol were used to initiate the ring-opening copolymerization (ROCOP) of maleic anhydride and propylene oxide to yield well-defined diblock and triblock copolymers of PEG-poly(propylene maleate) (PPM) and ultimately PEG-poly(propylene fumarate) (PPF) with different molecular mass PEG macroinitiators and block length ratios. Using continuous digital light processing (cDLP), hydrogels were photochemically printed from an aqueous solution which resulted in a 10-fold increase in elongation at break compared to traditional diethyl fumarate (DEF) based printing. Furthermore, PPF-PEG-PPF triblock hydrogels were also found to be biocompatible in vitro across a number of engineered MC3T3, NIH3T3, and primary Schwann cells.

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Published In

ACS Macro Letters

DOI

EISSN

2161-1653

Publication Date

October 16, 2018

Volume

7

Issue

10

Start / End Page

1254 / 1260

Related Subject Headings

  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0303 Macromolecular and Materials Chemistry
 

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Dilla, R. A., Motta, C. M. M., Snyder, S. R., Wilson, J. A., Wesdemiotis, C., & Becker, M. L. (2018). Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels. ACS Macro Letters, 7(10), 1254–1260. https://doi.org/10.1021/acsmacrolett.8b00720
Dilla, R. A., C. M. M. Motta, S. R. Snyder, J. A. Wilson, C. Wesdemiotis, and M. L. Becker. “Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels.” ACS Macro Letters 7, no. 10 (October 16, 2018): 1254–60. https://doi.org/10.1021/acsmacrolett.8b00720.
Dilla RA, Motta CMM, Snyder SR, Wilson JA, Wesdemiotis C, Becker ML. Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels. ACS Macro Letters. 2018 Oct 16;7(10):1254–60.
Dilla, R. A., et al. “Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels.” ACS Macro Letters, vol. 7, no. 10, Oct. 2018, pp. 1254–60. Scopus, doi:10.1021/acsmacrolett.8b00720.
Dilla RA, Motta CMM, Snyder SR, Wilson JA, Wesdemiotis C, Becker ML. Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Diblock and Triblock Copolymer Hydrogels. ACS Macro Letters. 2018 Oct 16;7(10):1254–1260.
Journal cover image

Published In

ACS Macro Letters

DOI

EISSN

2161-1653

Publication Date

October 16, 2018

Volume

7

Issue

10

Start / End Page

1254 / 1260

Related Subject Headings

  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0303 Macromolecular and Materials Chemistry