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Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications.

Publication ,  Journal Article
Dreger, NZ; Fan, Z; Zander, ZK; Tantisuwanno, C; Haines, MC; Waggoner, M; Parsell, T; Søndergaard, CS; Hiles, M; Premanandan, C; Becker, ML
Published in: Biomaterials
November 2018

The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l-valine-co-l-phenylalanine poly(ester urea) (PEU) copolymers were investigated for soft-tissue repair. Poly[(1-VAL-8)0.7-co-(1-PHE-6)0.3] showed the highest uniaxial mechanical properties (332.5 ± 3.5 MPa). Additionally, l-valine-co-l-phenylalanine poly(ester urea)s were blade coated on small intestine submucosa extracellular matrix (SIS-ECM) and found to enhance the burst test mechanical properties of SIS-ECM in composite films (force at break between 102.6 ± 6.5-151.4 ± 11.3 N). Free standing films of l-valine-co-l-phenylalanine PEUs were found to have superior extension at break when compared to SIS-ECM (averages between 1.2 and 1.9 cm and 1.2 cm respectively). Fibroblast (L-929) spreading, proliferation, and improved attachment over control were observed without toxicity in vitro, while a reduced inflammatory response at both 7 and 14 days post-implant was observed for poly[(1-VAL-8)⁠0.7-co-(1-PHE-6)⁠0.3] when compared to polypropylene in an in vivo rat hernia model. These results support the use of PEU copolymers as free-standing films or as composite materials in soft-tissue applications for hernia-repair.

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Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

November 2018

Volume

182

Start / End Page

44 / 57

Related Subject Headings

  • Valine
  • Urea
  • Rats
  • Polyesters
  • Phenylalanine
  • Mice
  • Materials Testing
  • Herniorrhaphy
  • Hernia
  • Elastic Modulus
 

Citation

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MLA
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Dreger, N. Z., Fan, Z., Zander, Z. K., Tantisuwanno, C., Haines, M. C., Waggoner, M., … Becker, M. L. (2018). Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. Biomaterials, 182, 44–57. https://doi.org/10.1016/j.biomaterials.2018.08.003
Dreger, Nathan Z., Zhaobo Fan, Zachary K. Zander, Chinnapatch Tantisuwanno, Molly C. Haines, Morgan Waggoner, Trenton Parsell, et al. “Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications.Biomaterials 182 (November 2018): 44–57. https://doi.org/10.1016/j.biomaterials.2018.08.003.
Dreger NZ, Fan Z, Zander ZK, Tantisuwanno C, Haines MC, Waggoner M, et al. Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. Biomaterials. 2018 Nov;182:44–57.
Dreger, Nathan Z., et al. “Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications.Biomaterials, vol. 182, Nov. 2018, pp. 44–57. Epmc, doi:10.1016/j.biomaterials.2018.08.003.
Dreger NZ, Fan Z, Zander ZK, Tantisuwanno C, Haines MC, Waggoner M, Parsell T, Søndergaard CS, Hiles M, Premanandan C, Becker ML. Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. Biomaterials. 2018 Nov;182:44–57.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

November 2018

Volume

182

Start / End Page

44 / 57

Related Subject Headings

  • Valine
  • Urea
  • Rats
  • Polyesters
  • Phenylalanine
  • Mice
  • Materials Testing
  • Herniorrhaphy
  • Hernia
  • Elastic Modulus