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Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing

Publication ,  Journal Article
Petersen, SR; Wilson, JA; Becker, ML
Published in: Macromolecules
August 28, 2018

Additive manufacturing has the potential to change medicine, but clinical applications are limited by a lack of resorbable, printable materials. Herein, we report the first synthesis of polylactone and poly(propylene fumarate) (PPF) block copolymers with well-defined molecular masses and molecular mass distributions using sequential, ring-opening polymerization and ring-opening copolymerization methods. These new copolymers represent a diverse platform of resorbable printable materials. Furthermore, these polymers open a previously unexplored range of accessible properties among stereolithographically printable materials, which we demonstrate by printing a polymer with a molecular mass nearly 4 times that of the largest PPF homopolymer previously printed. To further demonstrate the potential of these materials in regenerative medicine, we report the postprinting "click" functionalization of the material using a copper-mediated azide-alkyne cycloaddition.

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Published In

Macromolecules

DOI

EISSN

1520-5835

ISSN

0024-9297

Publication Date

August 28, 2018

Volume

51

Issue

16

Start / End Page

6202 / 6208

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Petersen, S. R., Wilson, J. A., & Becker, M. L. (2018). Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing. Macromolecules, 51(16), 6202–6208. https://doi.org/10.1021/acs.macromol.8b01372
Petersen, S. R., J. A. Wilson, and M. L. Becker. “Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing.” Macromolecules 51, no. 16 (August 28, 2018): 6202–8. https://doi.org/10.1021/acs.macromol.8b01372.
Petersen, S. R., et al. “Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing.” Macromolecules, vol. 51, no. 16, Aug. 2018, pp. 6202–08. Scopus, doi:10.1021/acs.macromol.8b01372.
Journal cover image

Published In

Macromolecules

DOI

EISSN

1520-5835

ISSN

0024-9297

Publication Date

August 28, 2018

Volume

51

Issue

16

Start / End Page

6202 / 6208

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences