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Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters.

Publication ,  Journal Article
Sallam, S; Luo, Y; Becker, ML; Wesdemiotis, C
Published in: European journal of mass spectrometry (Chichester, England)
December 2017

The biodegradable polyester copolymer poly(propylene fumarate) (PPF) is increasingly utilized in bone tissue engineering studies due to its suitability as inert cross-linkable scaffold material. The well-defined poly(propylene fumarate) oligomers needed for this purpose are synthesized by post-polymerization isomerization of poly(propylene maleate), which is prepared by ring opening polymerization of maleic anhydride and propylene oxide. In this study, multidimensional mass spectrometry methodologies, interfacing matrix-assisted laser desorption ionization and electrospray ionization with mass analysis, tandem mass spectrometry fragmentation and/or ion mobility mass spectrometry, have been employed to characterize the composition, end groups, chain connectivity and isomeric purity of the isomeric copolyesters poly(propylene maleate)and poly(propylene fumarate). It is demonstrated that the polymerization catalyst is incorporated into the polymer chain (as the initiating chain end) and that the poly(propylene maleate) to poly(propylene fumarate) isomerization using an amine base proceeds with quantitative yield. Hydrolytic degradation is shown not to alter the double bond geometry of the poly(propylene fumarate) or poly(propylene maleate) chains.

Duke Scholars

Published In

European journal of mass spectrometry (Chichester, England)

DOI

EISSN

1751-6838

ISSN

1469-0667

Publication Date

December 2017

Volume

23

Issue

6

Start / End Page

402 / 410

Related Subject Headings

  • Tandem Mass Spectrometry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectrometry, Mass, Electrospray Ionization
  • Polypropylenes
  • Polymerization
  • Polyesters
  • Molecular Structure
  • Maleic Anhydrides
  • Maleates
  • Isomerism
 

Citation

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MLA
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Sallam, S., Luo, Y., Becker, M. L., & Wesdemiotis, C. (2017). Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters. European Journal of Mass Spectrometry (Chichester, England), 23(6), 402–410. https://doi.org/10.1177/1469066717711401
Sallam, Sahar, Yuanyuan Luo, Matthew L. Becker, and Chrys Wesdemiotis. “Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters.European Journal of Mass Spectrometry (Chichester, England) 23, no. 6 (December 2017): 402–10. https://doi.org/10.1177/1469066717711401.
Sallam S, Luo Y, Becker ML, Wesdemiotis C. Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters. European journal of mass spectrometry (Chichester, England). 2017 Dec;23(6):402–10.
Sallam, Sahar, et al. “Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters.European Journal of Mass Spectrometry (Chichester, England), vol. 23, no. 6, Dec. 2017, pp. 402–10. Epmc, doi:10.1177/1469066717711401.
Sallam S, Luo Y, Becker ML, Wesdemiotis C. Multidimensional mass spectrometry characterization of isomeric biodegradable polyesters. European journal of mass spectrometry (Chichester, England). 2017 Dec;23(6):402–410.

Published In

European journal of mass spectrometry (Chichester, England)

DOI

EISSN

1751-6838

ISSN

1469-0667

Publication Date

December 2017

Volume

23

Issue

6

Start / End Page

402 / 410

Related Subject Headings

  • Tandem Mass Spectrometry
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectrometry, Mass, Electrospray Ionization
  • Polypropylenes
  • Polymerization
  • Polyesters
  • Molecular Structure
  • Maleic Anhydrides
  • Maleates
  • Isomerism