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Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds.

Publication ,  Journal Article
Wilson, JA; Luong, D; Kleinfehn, AP; Sallam, S; Wesdemiotis, C; Becker, ML
Published in: Journal of the American Chemical Society
January 2018

The ring-opening copolymerization of maleic anhydride and propylene oxide, using a functionalized primary alcohol initiator and magnesium 2,6-di-tert-butyl phenoxide as a catalyst, was investigated in order to produce high end-group fidelity poly(propylene maleate). Subsequent isomerization of the material into 3D printable poly(propylene fumarate) was utilized to produce thin films and scaffolds possessing groups that can be modified with bioactive groups postpolymerization and postprinting. The surface concentration of these modifiable groups was determined to be 30.0 ± 3.3 pmol·cm-2, and copper-mediated azide-alkyne cycloaddition was used to attach a small molecule dye and cell adhesive GRGDS peptides to the surface as a model system. The films were then studied for cytotoxicity and found to have high cell viability before and after surface modification.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

January 2018

Volume

140

Issue

1

Start / End Page

277 / 284

Related Subject Headings

  • Structure-Activity Relationship
  • Printing, Three-Dimensional
  • Polypropylenes
  • Polymerization
  • Molecular Structure
  • Mice
  • Maleates
  • Magnesium
  • General Chemistry
  • Fumarates
 

Citation

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Wilson, J. A., Luong, D., Kleinfehn, A. P., Sallam, S., Wesdemiotis, C., & Becker, M. L. (2018). Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds. Journal of the American Chemical Society, 140(1), 277–284. https://doi.org/10.1021/jacs.7b09978
Wilson, James A., Derek Luong, Alex P. Kleinfehn, Sahar Sallam, Chrys Wesdemiotis, and Matthew L. Becker. “Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds.Journal of the American Chemical Society 140, no. 1 (January 2018): 277–84. https://doi.org/10.1021/jacs.7b09978.
Wilson JA, Luong D, Kleinfehn AP, Sallam S, Wesdemiotis C, Becker ML. Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds. Journal of the American Chemical Society. 2018 Jan;140(1):277–84.
Wilson, James A., et al. “Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds.Journal of the American Chemical Society, vol. 140, no. 1, Jan. 2018, pp. 277–84. Epmc, doi:10.1021/jacs.7b09978.
Wilson JA, Luong D, Kleinfehn AP, Sallam S, Wesdemiotis C, Becker ML. Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds. Journal of the American Chemical Society. 2018 Jan;140(1):277–284.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

January 2018

Volume

140

Issue

1

Start / End Page

277 / 284

Related Subject Headings

  • Structure-Activity Relationship
  • Printing, Three-Dimensional
  • Polypropylenes
  • Polymerization
  • Molecular Structure
  • Mice
  • Maleates
  • Magnesium
  • General Chemistry
  • Fumarates