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Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.

Publication ,  Journal Article
Walker, JM; Bodamer, E; Krebs, O; Luo, Y; Kleinfehn, A; Becker, ML; Dean, D
Published in: Biomacromolecules
April 2017

Two distinct molecular masses of poly(propylene fumarate) (PPF) are combined with an additive manufacturing process to fabricate highly complex scaffolds possessing controlled chemical properties and porous architecture. Scaffolds were manufactured with two polymer molecular masses and two architecture styles. Degradation was assessed in an accelerated in vitro environment. The purpose of the degradation study is not to model or mimic in vivo degradation, but to efficiently compare the effect of modulating scaffold properties. This is the first study addressing degradation of chain-growth synthesized PPF, a process that allows for considerably more control over molecular mass distribution. It demonstrates that, with greater process control, not only is scaffold fabrication reproducible, but the mechanical properties and degradation kinetics can be tailored by altering the physical properties of the scaffold. This is a clear step forward in using PPF to address unmet medical needs while meeting regulatory demands and ultimately obtaining clinical relevancy.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

April 2017

Volume

18

Issue

4

Start / End Page

1419 / 1425

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Surface Properties
  • Stress, Mechanical
  • Printing, Three-Dimensional
  • Porosity
  • Polypropylenes
  • Polymers
  • Materials Testing
  • Hydrogen-Ion Concentration
 

Citation

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Walker, J. M., Bodamer, E., Krebs, O., Luo, Y., Kleinfehn, A., Becker, M. L., & Dean, D. (2017). Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds. Biomacromolecules, 18(4), 1419–1425. https://doi.org/10.1021/acs.biomac.7b00146
Walker, Jason M., Emily Bodamer, Olivia Krebs, Yuanyuan Luo, Alex Kleinfehn, Matthew L. Becker, and David Dean. “Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.Biomacromolecules 18, no. 4 (April 2017): 1419–25. https://doi.org/10.1021/acs.biomac.7b00146.
Walker JM, Bodamer E, Krebs O, Luo Y, Kleinfehn A, Becker ML, et al. Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds. Biomacromolecules. 2017 Apr;18(4):1419–25.
Walker, Jason M., et al. “Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.Biomacromolecules, vol. 18, no. 4, Apr. 2017, pp. 1419–25. Epmc, doi:10.1021/acs.biomac.7b00146.
Walker JM, Bodamer E, Krebs O, Luo Y, Kleinfehn A, Becker ML, Dean D. Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds. Biomacromolecules. 2017 Apr;18(4):1419–1425.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

April 2017

Volume

18

Issue

4

Start / End Page

1419 / 1425

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Surface Properties
  • Stress, Mechanical
  • Printing, Three-Dimensional
  • Porosity
  • Polypropylenes
  • Polymers
  • Materials Testing
  • Hydrogen-Ion Concentration