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Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.

Publication ,  Journal Article
Zheng, J; Kontoveros, D; Lin, F; Hua, G; Reneker, DH; Becker, ML; Willits, RK
Published in: Biomacromolecules
January 2015

Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

January 2015

Volume

16

Issue

1

Start / End Page

357 / 363

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Schwann Cells
  • Rats
  • Polymers
  • Oligopeptides
  • Nanofibers
  • Click Chemistry
  • Cell Proliferation
  • Cell Line
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zheng, J., Kontoveros, D., Lin, F., Hua, G., Reneker, D. H., Becker, M. L., & Willits, R. K. (2015). Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers. Biomacromolecules, 16(1), 357–363. https://doi.org/10.1021/bm501552t
Zheng, Jukuan, Dimitria Kontoveros, Fei Lin, Geng Hua, Darrell H. Reneker, Matthew L. Becker, and Rebecca K. Willits. “Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.Biomacromolecules 16, no. 1 (January 2015): 357–63. https://doi.org/10.1021/bm501552t.
Zheng J, Kontoveros D, Lin F, Hua G, Reneker DH, Becker ML, et al. Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers. Biomacromolecules. 2015 Jan;16(1):357–63.
Zheng, Jukuan, et al. “Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.Biomacromolecules, vol. 16, no. 1, Jan. 2015, pp. 357–63. Epmc, doi:10.1021/bm501552t.
Zheng J, Kontoveros D, Lin F, Hua G, Reneker DH, Becker ML, Willits RK. Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers. Biomacromolecules. 2015 Jan;16(1):357–363.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

January 2015

Volume

16

Issue

1

Start / End Page

357 / 363

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Schwann Cells
  • Rats
  • Polymers
  • Oligopeptides
  • Nanofibers
  • Click Chemistry
  • Cell Proliferation
  • Cell Line