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Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.

Publication ,  Journal Article
Stakleff, KS; Lin, F; Smith Callahan, LA; Wade, MB; Esterle, A; Miller, J; Graham, M; Becker, ML
Published in: Acta biomaterialia
February 2013

Materials currently used for the treatment of bone defects include ceramics, polymeric scaffolds and composites, which are often impregnated with recombinant growth factors and other bioactive substances. While these materials have seen instances of success, each has inherent shortcomings including prohibitive expense, poor protein stability, poorly defined growth factor release and less than desirable mechanical properties. We have developed a novel class of amino acid-based poly(ester urea)s (PEU) materials which are biodegradable in vivo and possess mechanical properties superior to conventionally used polyesters (<3.5 GPa) available currently to clinicians and medical providers. We report the use of a short peptide derived from osteogenic growth peptide (OGP) as a covalent crosslinker for the PEU materials. In addition to imparting specific bioactive signaling, our crosslinking studies show that the mechanical properties increase proportionally when 0.5% and 1.0% concentrations of the OGP crosslinker are added. Our results in vitro and in an in vivo subcutaneous rat model show the OGP-based crosslinkers, which are small fragments of growth factors that are normally soluble, exhibit enhanced proliferative activity, accelerated degradation properties and concentration dependent bioactivity when immobilized.

Duke Scholars

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Published In

Acta biomaterialia

DOI

EISSN

1878-7568

ISSN

1742-7061

Publication Date

February 2013

Volume

9

Issue

2

Start / End Page

5132 / 5142

Related Subject Headings

  • Tensile Strength
  • Rats, Sprague-Dawley
  • Rats
  • Polyesters
  • Molecular Sequence Data
  • Mice
  • Mechanical Phenomena
  • Materials Testing
  • Male
  • Intercellular Signaling Peptides and Proteins
 

Citation

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Stakleff, K. S., Lin, F., Smith Callahan, L. A., Wade, M. B., Esterle, A., Miller, J., … Becker, M. L. (2013). Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. Acta Biomaterialia, 9(2), 5132–5142. https://doi.org/10.1016/j.actbio.2012.08.035
Stakleff, Kimberly Sloan, Fei Lin, Laura A. Smith Callahan, Mary Beth Wade, Andrew Esterle, James Miller, Matthew Graham, and Matthew L. Becker. “Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.Acta Biomaterialia 9, no. 2 (February 2013): 5132–42. https://doi.org/10.1016/j.actbio.2012.08.035.
Stakleff KS, Lin F, Smith Callahan LA, Wade MB, Esterle A, Miller J, et al. Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. Acta biomaterialia. 2013 Feb;9(2):5132–42.
Stakleff, Kimberly Sloan, et al. “Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.Acta Biomaterialia, vol. 9, no. 2, Feb. 2013, pp. 5132–42. Epmc, doi:10.1016/j.actbio.2012.08.035.
Stakleff KS, Lin F, Smith Callahan LA, Wade MB, Esterle A, Miller J, Graham M, Becker ML. Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. Acta biomaterialia. 2013 Feb;9(2):5132–5142.
Journal cover image

Published In

Acta biomaterialia

DOI

EISSN

1878-7568

ISSN

1742-7061

Publication Date

February 2013

Volume

9

Issue

2

Start / End Page

5132 / 5142

Related Subject Headings

  • Tensile Strength
  • Rats, Sprague-Dawley
  • Rats
  • Polyesters
  • Molecular Sequence Data
  • Mice
  • Mechanical Phenomena
  • Materials Testing
  • Male
  • Intercellular Signaling Peptides and Proteins