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Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth.

Publication ,  Journal Article
Stanley, SK; Becker, ML; Lin, EK; Wu, W-L
Published in: Langmuir : the ACS journal of surfaces and colloids
September 2009

Peptides have been shown to mediate the reduction and clustering of inorganic ions during biomineralization processes to build nanomaterials with well-defined shape, size, and composition. This precise control has been linked to specific amino acid sequence; however, there is a lack of information about the role of peptides during mineralization. Here, we investigate the nucleation and growth behavior of Au nanocrystals that are mediated by the engineered peptide AYSSGAPPMPPF. Unlike other nanocrystal synthesis schemes, this peptide produces Au nanocrystals from Au(III) ions at very low relative peptide concentrations, at ambient temperature, and in water at neutral pH. Our data show that (i) the peptide AYSSGAPPMPPF actually inhibits nucleation and growth of nanocrystals, (ii) HEPES plays an active chemical role as the reducing agent, and (iii) HAuCl4 accelerates the kinetics of nanoparticle nucleation and growth. Herein, we propose empirical rate laws for nucleation and growth of Au nanocrystals and compare kinetic rate laws for this peptide, citrate, and various other polymer ligands. We find that the peptide belongs to a unique class of nonreducing inhibitor ligands regulating the surface-reaction-limited growth of nanocrystals.

Duke Scholars

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Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

September 2009

Volume

25

Issue

18

Start / End Page

10886 / 10892

Related Subject Headings

  • Temperature
  • Peptides
  • Metal Nanoparticles
  • Kinetics
  • Hydrogen-Ion Concentration
  • HEPES
  • Gold Compounds
  • Gold
  • Citric Acid
  • Chlorides
 

Citation

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ICMJE
MLA
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Stanley, S. K., Becker, M. L., Lin, E. K., & Wu, W.-L. (2009). Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. Langmuir : The ACS Journal of Surfaces and Colloids, 25(18), 10886–10892. https://doi.org/10.1021/la901222k
Stanley, Scott K., Matthew L. Becker, Eric K. Lin, and Wen-li Wu. “Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth.Langmuir : The ACS Journal of Surfaces and Colloids 25, no. 18 (September 2009): 10886–92. https://doi.org/10.1021/la901222k.
Stanley SK, Becker ML, Lin EK, Wu W-L. Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. Langmuir : the ACS journal of surfaces and colloids. 2009 Sep;25(18):10886–92.
Stanley, Scott K., et al. “Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 25, no. 18, Sept. 2009, pp. 10886–92. Epmc, doi:10.1021/la901222k.
Stanley SK, Becker ML, Lin EK, Wu W-L. Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. Langmuir : the ACS journal of surfaces and colloids. 2009 Sep;25(18):10886–10892.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

September 2009

Volume

25

Issue

18

Start / End Page

10886 / 10892

Related Subject Headings

  • Temperature
  • Peptides
  • Metal Nanoparticles
  • Kinetics
  • Hydrogen-Ion Concentration
  • HEPES
  • Gold Compounds
  • Gold
  • Citric Acid
  • Chlorides