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Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate.

Publication ,  Journal Article
Park, JJ; Weiger, MC; Lacerda, SHDP; Pristinski, D; Becker, ML; Douglas, JF; Raghavan, D; Karim, A
Published in: Langmuir : the ACS journal of surfaces and colloids
April 2010

The kinetics of nanoparticle (NP) adsorption on a model biological interface (collagen) is measured in microfluidic channels using surface plasmon resonance (SPR) imaging over a range of CdSe/ZnS quantum dot concentrations to investigate the underlying binding process. Spherical CdSe/ZnS core-shell NP, derivatized with 3-mercaptopropionic acid (3-MPA), were considered to be model NPs because of their widespread use in biological applications and their relatively monodisperse size. The kinetic adsorption data suggests that the binding between the NP and the collagen substrate is irreversible at room temperature (pH approximately 7.4), and this type of adsorption process was further characterized in the context of a surface absorption model. Specifically, diffusion-limited adsorption was found to predominate the adsorption process at lower concentrations (<0.4 micromol/L), and NP adsorption was reaction-limited at higher concentration (>0.4 micromol/L). A limited pH study of our system indicates that NPs desorb from collagen under acidic conditions (pH 5.5); no significant desorption was observed under neutral and basic pH conditions. These observations are consistent with electrostatic interactions being the dominant force governing NP desorption from collagen substrates. Our present methodology for characterizing the seemingly irreversible NP adsorption complements our earlier study where NP adsorption onto weakly adsorbing surfaces (self-assembled monolayers) was characterized by Langmuir NP adsorption measurements.

Duke Scholars

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

April 2010

Volume

26

Issue

7

Start / End Page

4822 / 4830

Related Subject Headings

  • Zinc Compounds
  • Thermodynamics
  • Temperature
  • Surface Plasmon Resonance
  • Selenium Compounds
  • Quantum Dots
  • Nanoparticles
  • Models, Theoretical
  • Kinetics
  • Hydrogen-Ion Concentration
 

Citation

APA
Chicago
ICMJE
MLA
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Park, J. J., Weiger, M. C., Lacerda, S. H. D. P., Pristinski, D., Becker, M. L., Douglas, J. F., … Karim, A. (2010). Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. Langmuir : The ACS Journal of Surfaces and Colloids, 26(7), 4822–4830. https://doi.org/10.1021/la903581w
Park, Jung Jin, Michael C. Weiger, Silvia H De Paoli Lacerda, Denis Pristinski, Matthew L. Becker, Jack F. Douglas, Dharmaraj Raghavan, and Alamgir Karim. “Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate.Langmuir : The ACS Journal of Surfaces and Colloids 26, no. 7 (April 2010): 4822–30. https://doi.org/10.1021/la903581w.
Park JJ, Weiger MC, Lacerda SHDP, Pristinski D, Becker ML, Douglas JF, et al. Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. Langmuir : the ACS journal of surfaces and colloids. 2010 Apr;26(7):4822–30.
Park, Jung Jin, et al. “Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 26, no. 7, Apr. 2010, pp. 4822–30. Epmc, doi:10.1021/la903581w.
Park JJ, Weiger MC, Lacerda SHDP, Pristinski D, Becker ML, Douglas JF, Raghavan D, Karim A. Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. Langmuir : the ACS journal of surfaces and colloids. 2010 Apr;26(7):4822–4830.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

April 2010

Volume

26

Issue

7

Start / End Page

4822 / 4830

Related Subject Headings

  • Zinc Compounds
  • Thermodynamics
  • Temperature
  • Surface Plasmon Resonance
  • Selenium Compounds
  • Quantum Dots
  • Nanoparticles
  • Models, Theoretical
  • Kinetics
  • Hydrogen-Ion Concentration