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Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.

Publication ,  Journal Article
Li, Y; Bonner, MR; Browne, RW; Deng, F; Tian, L; Jim Zhang, J; Swanson, M; Rittenhouse-Olson, K; Farhat, Z; Mu, L
Published in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
November 2019

Background: Despite the in vitro and in vivo evidence, studies are limited in evaluating whether chemokines are potential inflammatory mediators in response to air pollution exposure in humans. Methods: We conducted a panel study coinciding with the Beijing Olympics, when temporary air pollution controls were implemented. We measured a suite of serum chemokines among healthy adults before, during and after the Olympics, respectively. Linear mixed-effect models were used to evaluate changes in chemokine levels over the three time periods. Results: In response to the 50% drop in air pollution levels during the games, levels of RANTES, MCP-2, and TARC decreased by 25.8%, 20.9% and 35.3%, respectively (p < 0.001) from pre-Olympics, and then increased by 45.8%, 34.9% and 61.5%, respectively (p < 0.001) after the games when air pollution levels went up again. Similar patterns were observed in subgroup analyses by sex, age, smoking and body mass index. GRO-α and IL-8 decreased significantly during the games (22.5% and 30.4%), and increased non-significantly after the games. Eotaxin-1 only increased significantly from during- to post-games. Conclusions: The strongest associations with air pollution levels were observed among RANTES, TARC and MCP-2. Those chemokines may play important roles in the air pollution-induced inflammatory pathway.

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Published In

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

DOI

EISSN

1366-5804

ISSN

1354-750X

Publication Date

November 2019

Volume

24

Issue

7

Start / End Page

712 / 719

Related Subject Headings

  • Toxicology
  • Sports
  • Male
  • Humans
  • Female
  • Environmental Monitoring
  • Chemokines
  • Chemokine CCL8
  • Chemokine CCL5
  • Chemokine CCL17
 

Citation

APA
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ICMJE
MLA
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Li, Y., Bonner, M. R., Browne, R. W., Deng, F., Tian, L., Jim Zhang, J., … Mu, L. (2019). Responses of serum chemokines to dramatic changes of air pollution levels, a panel study. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 24(7), 712–719. https://doi.org/10.1080/1354750x.2019.1658803
Li, Yanli, Matthew R. Bonner, Richard W. Browne, Furong Deng, Lili Tian, Junfeng Jim Zhang, Mya Swanson, Kate Rittenhouse-Olson, Zeinab Farhat, and Lina Mu. “Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 24, no. 7 (November 2019): 712–19. https://doi.org/10.1080/1354750x.2019.1658803.
Li Y, Bonner MR, Browne RW, Deng F, Tian L, Jim Zhang J, et al. Responses of serum chemokines to dramatic changes of air pollution levels, a panel study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2019 Nov;24(7):712–9.
Li, Yanli, et al. “Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, vol. 24, no. 7, Nov. 2019, pp. 712–19. Epmc, doi:10.1080/1354750x.2019.1658803.
Li Y, Bonner MR, Browne RW, Deng F, Tian L, Jim Zhang J, Swanson M, Rittenhouse-Olson K, Farhat Z, Mu L. Responses of serum chemokines to dramatic changes of air pollution levels, a panel study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2019 Nov;24(7):712–719.

Published In

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

DOI

EISSN

1366-5804

ISSN

1354-750X

Publication Date

November 2019

Volume

24

Issue

7

Start / End Page

712 / 719

Related Subject Headings

  • Toxicology
  • Sports
  • Male
  • Humans
  • Female
  • Environmental Monitoring
  • Chemokines
  • Chemokine CCL8
  • Chemokine CCL5
  • Chemokine CCL17