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Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample.

Publication ,  Journal Article
Silverberg, JI; Kwa, L; Kwa, MC; Laumann, AE; Ardalan, K
Published in: Rheumatology (Oxford)
April 1, 2018

OBJECTIVE: JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. METHODS: Data from the 2002-12 National Inpatient Sample was analysed, including ∼20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). RESULTS: JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. CONCLUSIONS: There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.

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Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

April 1, 2018

Volume

57

Issue

4

Start / End Page

694 / 702

Location

England

Related Subject Headings

  • United States
  • Sex Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Population Surveillance
  • Odds Ratio
  • Male
  • Inpatients
  • Infant, Newborn
 

Citation

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Silverberg, J. I., Kwa, L., Kwa, M. C., Laumann, A. E., & Ardalan, K. (2018). Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample. Rheumatology (Oxford), 57(4), 694–702. https://doi.org/10.1093/rheumatology/kex465
Silverberg, Jonathan I., Lauren Kwa, Michael C. Kwa, Anne E. Laumann, and Kaveh Ardalan. “Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample.Rheumatology (Oxford) 57, no. 4 (April 1, 2018): 694–702. https://doi.org/10.1093/rheumatology/kex465.
Silverberg JI, Kwa L, Kwa MC, Laumann AE, Ardalan K. Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample. Rheumatology (Oxford). 2018 Apr 1;57(4):694–702.
Silverberg, Jonathan I., et al. “Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample.Rheumatology (Oxford), vol. 57, no. 4, Apr. 2018, pp. 694–702. Pubmed, doi:10.1093/rheumatology/kex465.
Silverberg JI, Kwa L, Kwa MC, Laumann AE, Ardalan K. Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample. Rheumatology (Oxford). 2018 Apr 1;57(4):694–702.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

April 1, 2018

Volume

57

Issue

4

Start / End Page

694 / 702

Location

England

Related Subject Headings

  • United States
  • Sex Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Population Surveillance
  • Odds Ratio
  • Male
  • Inpatients
  • Infant, Newborn