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Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma.

Publication ,  Journal Article
Qiu, W; Wang, B; Gao, Y; Tian, Y; Tian, M; Chen, Y; Xu, L; Yao, T-P; Li, P; Yang, P
Published in: Hepatology
June 2020

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is often accompanied by resistance to immunotherapies despite the presence of tumor-infiltrating lymphocytes. We report that histone deacetylase 6 (HDAC6) represses interleukin-17 (IL-17)-producing helper T (TH 17) cell pathogenicity and the antitumor immune response, dependent on its deacetylase activity. APPROACH AND RESULTS: Adoptive transfer of HDAC6-deficient TH 17 cells impedes HCC growth, dependent on elevated IL-17A, by enhancing the production of antitumor cytokine and cluster of differentiation 8-positive (CD8+) T cell-mediated antitumor responses. Intriguingly, HDAC6-depleted T cells trigger programmed cell death protein 1 (PD-1)-PD-1 ligand 1 expression to achieve a strong synergistic effect to sensitize advanced HCC to an immune checkpoint blocker, while blockade of IL-17A partially suppresses it. Mechanistically, HDAC6 limits TH 17 pathogenicity and the antitumor effect through regulating forkhead box protein O1 (FoxO1). HDAC6 binds and deacetylates cytosolic FoxO1 at K242, which is required for its nuclear translocation and stabilization to repress retinoic acid-related orphan receptor gamma (RoRγt), the transcription factor of TH 17 cell. This regulation of HDAC6 for murine and human TH 17 cell is highly conserved. CONCLUSIONS: These results demonstrate that targeting the cytosolic HDAC6-FoxO1 axis reprograms the pathogenicity and antitumor response of TH 17 cells in HCC, with a pathogenicity-driven responsiveness to facilitate immunotherapies.

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Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

June 2020

Volume

71

Issue

6

Start / End Page

1967 / 1987

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Signal Transduction
  • Retinoic Acid Receptor gamma
  • Receptors, Retinoic Acid
  • Programmed Cell Death 1 Receptor
  • Mice
  • Liver Neoplasms
  • Interleukin-17
  • Immunotherapy
  • Immune Checkpoint Inhibitors
 

Citation

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MLA
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Qiu, W., Wang, B., Gao, Y., Tian, Y., Tian, M., Chen, Y., … Yang, P. (2020). Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. Hepatology, 71(6), 1967–1987. https://doi.org/10.1002/hep.30960
Qiu, Weinan, Bin Wang, Yanan Gao, Yuan Tian, Meijie Tian, Yuanying Chen, Li Xu, Tso-Pang Yao, Peng Li, and Pengyuan Yang. “Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma.Hepatology 71, no. 6 (June 2020): 1967–87. https://doi.org/10.1002/hep.30960.
Qiu, Weinan, et al. “Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma.Hepatology, vol. 71, no. 6, June 2020, pp. 1967–87. Pubmed, doi:10.1002/hep.30960.
Qiu W, Wang B, Gao Y, Tian Y, Tian M, Chen Y, Xu L, Yao T-P, Li P, Yang P. Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. Hepatology. 2020 Jun;71(6):1967–1987.
Journal cover image

Published In

Hepatology

DOI

EISSN

1527-3350

Publication Date

June 2020

Volume

71

Issue

6

Start / End Page

1967 / 1987

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Signal Transduction
  • Retinoic Acid Receptor gamma
  • Receptors, Retinoic Acid
  • Programmed Cell Death 1 Receptor
  • Mice
  • Liver Neoplasms
  • Interleukin-17
  • Immunotherapy
  • Immune Checkpoint Inhibitors