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Acute resistance exercise augments integrative myofibrillar protein synthesis.

Publication ,  Journal Article
Gasier, HG; Fluckey, JD; Previs, SF; Wiggs, MP; Riechman, SE
Published in: Metabolism
February 2012

The purpose of this study was to determine whether an acute bout of high-intensity resistance exercise (RE) would augment integrative mixed muscle and myofibrillar protein fractional synthesis rates (FSRs) when total energy and macronutrient intake was controlled. Twelve healthy young men were studied over 24 hours and performed an acute bout of exhaustive (5 sets until volitional failure of their 85% 1-repetition maximum) unilateral leg press and knee extension exercise, such that one leg was exercised (EX) and the other served as a control (CON). (2)H(2)O (70%) was provided to measure mixed muscle and myofibrillar FSR, and muscle biopsies (vastus lateralis) were collected from the EX and CON legs 16 hours following the RE session. (2)H-labeling of body water over the course of the experiment was 0.32 ± 0.01 mole percent excess. Interestingly, integrative mixed muscle FSR (percent per hour) was similar between the CON (0.76% ± 0.08%) and EX (0.69% ± 0.06%) legs. In contrast, upon determination of myofibrillar FSR, there was an RE effect (EX, 0.94% ± 0.16% vs CON, 0.75% ± 0.08%; P < .05). High-intensity RE without prior training impacts integrative myofibrillar 24-hour FSR, perhaps without altering total responses.

Duke Scholars

Published In

Metabolism

DOI

EISSN

1532-8600

Publication Date

February 2012

Volume

61

Issue

2

Start / End Page

153 / 156

Location

United States

Related Subject Headings

  • Young Adult
  • Up-Regulation
  • Time Factors
  • Resistance Training
  • Range of Motion, Articular
  • Protein Biosynthesis
  • Physical Exertion
  • Myofibrils
  • Muscle, Skeletal
  • Muscle Proteins
 

Citation

APA
Chicago
ICMJE
MLA
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Gasier, H. G., Fluckey, J. D., Previs, S. F., Wiggs, M. P., & Riechman, S. E. (2012). Acute resistance exercise augments integrative myofibrillar protein synthesis. Metabolism, 61(2), 153–156. https://doi.org/10.1016/j.metabol.2011.07.001
Gasier, Heath G., James D. Fluckey, Stephen F. Previs, Michael P. Wiggs, and Steven E. Riechman. “Acute resistance exercise augments integrative myofibrillar protein synthesis.Metabolism 61, no. 2 (February 2012): 153–56. https://doi.org/10.1016/j.metabol.2011.07.001.
Gasier HG, Fluckey JD, Previs SF, Wiggs MP, Riechman SE. Acute resistance exercise augments integrative myofibrillar protein synthesis. Metabolism. 2012 Feb;61(2):153–6.
Gasier, Heath G., et al. “Acute resistance exercise augments integrative myofibrillar protein synthesis.Metabolism, vol. 61, no. 2, Feb. 2012, pp. 153–56. Pubmed, doi:10.1016/j.metabol.2011.07.001.
Gasier HG, Fluckey JD, Previs SF, Wiggs MP, Riechman SE. Acute resistance exercise augments integrative myofibrillar protein synthesis. Metabolism. 2012 Feb;61(2):153–156.
Journal cover image

Published In

Metabolism

DOI

EISSN

1532-8600

Publication Date

February 2012

Volume

61

Issue

2

Start / End Page

153 / 156

Location

United States

Related Subject Headings

  • Young Adult
  • Up-Regulation
  • Time Factors
  • Resistance Training
  • Range of Motion, Articular
  • Protein Biosynthesis
  • Physical Exertion
  • Myofibrils
  • Muscle, Skeletal
  • Muscle Proteins