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Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

Publication ,  Journal Article
Shtein, RM; Shen, JF; Kuo, AN; Hammersmith, KM; Li, JY; Weikert, MP
Published in: Ophthalmology
January 2020

PURPOSE: To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS: Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citations, which were reviewed in abstract form. Of these, 48 were selected for a full-text review, and 13 met the inclusion criteria and were assigned a quality-of-evidence rating by the panel methodologist. Eight of these studies were rated level II and 5 were rated level III; there were no level I studies. RESULTS: This analysis included 10 studies of the use of autologous serum-based eye drops for severe dry eye disease and 4 studies of persistent epithelial defect. Several studies showed good effectiveness, with some improvement in symptoms, signs, or both. Eight of the studies reported improved symptoms for severe dry eye disease, and all noted improvement in at least 1 clinical sign. For persistent epithelial defects, all of the studies showed improvement, with 3 of the 4 demonstrating an improvement rate of more than 90%. Adverse events were rare. CONCLUSIONS: Although autologous serum-based tears may be effective in the treatment of severe dry eye and persistent epithelial defect, conclusions are limited owing to the absence of controlled trials.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2020

Volume

127

Issue

1

Start / End Page

128 / 133

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Technology Assessment, Biomedical
  • Serum
  • Ophthalmology & Optometry
  • Ophthalmology
  • Ophthalmic Solutions
  • Humans
  • Epithelium, Corneal
  • Dry Eye Syndromes
 

Citation

APA
Chicago
ICMJE
MLA
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Shtein, R. M., Shen, J. F., Kuo, A. N., Hammersmith, K. M., Li, J. Y., & Weikert, M. P. (2020). Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology. Ophthalmology, 127(1), 128–133. https://doi.org/10.1016/j.ophtha.2019.08.018
Shtein, Roni M., Joanne F. Shen, Anthony N. Kuo, Kristin M. Hammersmith, Jennifer Y. Li, and Mitchell P. Weikert. “Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.Ophthalmology 127, no. 1 (January 2020): 128–33. https://doi.org/10.1016/j.ophtha.2019.08.018.
Shtein RM, Shen JF, Kuo AN, Hammersmith KM, Li JY, Weikert MP. Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology. Ophthalmology. 2020 Jan;127(1):128–33.
Shtein, Roni M., et al. “Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.Ophthalmology, vol. 127, no. 1, Jan. 2020, pp. 128–33. Pubmed, doi:10.1016/j.ophtha.2019.08.018.
Shtein RM, Shen JF, Kuo AN, Hammersmith KM, Li JY, Weikert MP. Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology. Ophthalmology. 2020 Jan;127(1):128–133.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2020

Volume

127

Issue

1

Start / End Page

128 / 133

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Technology Assessment, Biomedical
  • Serum
  • Ophthalmology & Optometry
  • Ophthalmology
  • Ophthalmic Solutions
  • Humans
  • Epithelium, Corneal
  • Dry Eye Syndromes