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Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.

Publication ,  Journal Article
Mishra, SK; Wheeler, JJ; Pitake, S; Ding, H; Jiang, C; Fukuyama, T; Paps, JS; Ralph, P; Coyne, J; Parkington, M; DeBrecht, J; Cruse, GP ...
Published in: Cell Rep
April 7, 2020

Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the integrin αVβ3 expressed on a subset of sensory neurons as the periostin receptor. Using pharmacological and genetic approaches, we inhibited the function of neuronal integrin αVβ3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch.

Duke Scholars

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

April 7, 2020

Volume

31

Issue

1

Start / End Page

107472

Location

United States

Related Subject Headings

  • Skin
  • Sensory Receptor Cells
  • Pruritus
  • Primates
  • Mice
  • Male
  • Keratinocytes
  • Integrins
  • Integrin beta3
  • Integrin alpha5
 

Citation

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Mishra, S. K., Wheeler, J. J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2020). Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep, 31(1), 107472. https://doi.org/10.1016/j.celrep.2020.03.036
Mishra, Santosh K., Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, et al. “Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.Cell Rep 31, no. 1 (April 7, 2020): 107472. https://doi.org/10.1016/j.celrep.2020.03.036.
Mishra SK, Wheeler JJ, Pitake S, Ding H, Jiang C, Fukuyama T, et al. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020 Apr 7;31(1):107472.
Mishra, Santosh K., et al. “Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.Cell Rep, vol. 31, no. 1, Apr. 2020, p. 107472. Pubmed, doi:10.1016/j.celrep.2020.03.036.
Mishra SK, Wheeler JJ, Pitake S, Ding H, Jiang C, Fukuyama T, Paps JS, Ralph P, Coyne J, Parkington M, DeBrecht J, Ehrhardt-Humbert LC, Cruse GP, Bäumer W, Ji R-R, Ko M-C, Olivry T. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020 Apr 7;31(1):107472.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

April 7, 2020

Volume

31

Issue

1

Start / End Page

107472

Location

United States

Related Subject Headings

  • Skin
  • Sensory Receptor Cells
  • Pruritus
  • Primates
  • Mice
  • Male
  • Keratinocytes
  • Integrins
  • Integrin beta3
  • Integrin alpha5