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Evaluating Skilled Prehension in Mice Using an Auto-Trainer.

Publication ,  Journal Article
Hubbard, R; Dunthorn, J; O'Brien, RJ; Tasch, D; Tasch, U; Zeiler, SR
Published in: J Vis Exp
September 12, 2019

We describe a method to introduce naïve mice to a novel prehension (reach-to-grasp) task. Mice are housed singly in cages with a frontal slot that permits the mouse to reach out of its cage and retrieve food pellets. Minimal food restriction is employed to encourage the mice to perform the food retrieval from the slot. As the mice begin to associate coming to the slot for food, the pellets are manually pulled away to stimulate extension and pronation of their paw to grasp and retrieve the pellet through the frontal slot. When the mice begin to reach for the pellets as they arrive at the slot, the behavioral assay can be performed by measuring the rate at which they successfully grasp and retrieve the desired pellet. They are then introduced to an auto-trainer that automates both the process of providing food pellets for the mouse to grasp, and the recording of successful and failed reaching and grasping attempts. This allows for the collection of reaching data for multiple mice with minimal effort, to be used in experimental analysis as appropriate.

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Published In

J Vis Exp

DOI

EISSN

1940-087X

Publication Date

September 12, 2019

Issue

151

Location

United States

Related Subject Headings

  • Psychomotor Performance
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Hand Strength
  • Food
  • Behavior, Animal
  • Animals
  • 3101 Biochemistry and cell biology
  • 1702 Cognitive Sciences
 

Citation

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Hubbard, R., Dunthorn, J., O’Brien, R. J., Tasch, D., Tasch, U., & Zeiler, S. R. (2019). Evaluating Skilled Prehension in Mice Using an Auto-Trainer. J Vis Exp, (151). https://doi.org/10.3791/59784
Hubbard, Robert, Jason Dunthorn, Richard J. O’Brien, Dan Tasch, Uri Tasch, and Steven R. Zeiler. “Evaluating Skilled Prehension in Mice Using an Auto-Trainer.J Vis Exp, no. 151 (September 12, 2019). https://doi.org/10.3791/59784.
Hubbard R, Dunthorn J, O’Brien RJ, Tasch D, Tasch U, Zeiler SR. Evaluating Skilled Prehension in Mice Using an Auto-Trainer. J Vis Exp. 2019 Sep 12;(151).
Hubbard, Robert, et al. “Evaluating Skilled Prehension in Mice Using an Auto-Trainer.J Vis Exp, no. 151, Sept. 2019. Pubmed, doi:10.3791/59784.
Hubbard R, Dunthorn J, O’Brien RJ, Tasch D, Tasch U, Zeiler SR. Evaluating Skilled Prehension in Mice Using an Auto-Trainer. J Vis Exp. 2019 Sep 12;(151).

Published In

J Vis Exp

DOI

EISSN

1940-087X

Publication Date

September 12, 2019

Issue

151

Location

United States

Related Subject Headings

  • Psychomotor Performance
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Hand Strength
  • Food
  • Behavior, Animal
  • Animals
  • 3101 Biochemistry and cell biology
  • 1702 Cognitive Sciences