Molecular Biology and Evolution of Cancer: From Discovery to Action.
Publication
, Journal Article
Somarelli, JA; Gardner, H; Cannataro, VL; Gunady, EF; Boddy, AM; Johnson, NA; Fisk, JN; Gaffney, SG; Chuang, JH; Li, S; Ciccarelli, FD ...
Published in: Mol Biol Evol
February 1, 2020
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.
Duke Scholars
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Published In
Mol Biol Evol
DOI
EISSN
1537-1719
Publication Date
February 1, 2020
Volume
37
Issue
2
Start / End Page
320 / 326
Location
United States
Related Subject Headings
- Stem Cell Niche
- Phylogeny
- Neoplasms
- Humans
- Genomics
- Genetic Fitness
- Evolutionary Biology
- Evolution, Molecular
- Disease Progression
- 3105 Genetics
Citation
APA
Chicago
ICMJE
MLA
NLM
Somarelli, J. A., Gardner, H., Cannataro, V. L., Gunady, E. F., Boddy, A. M., Johnson, N. A., … Townsend, J. P. (2020). Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol, 37(2), 320–326. https://doi.org/10.1093/molbev/msz242
Somarelli, Jason A., Heather Gardner, Vincent L. Cannataro, Ella F. Gunady, Amy M. Boddy, Norman A. Johnson, Jeffrey Nicholas Fisk, et al. “Molecular Biology and Evolution of Cancer: From Discovery to Action.” Mol Biol Evol 37, no. 2 (February 1, 2020): 320–26. https://doi.org/10.1093/molbev/msz242.
Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, et al. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 Feb 1;37(2):320–6.
Somarelli, Jason A., et al. “Molecular Biology and Evolution of Cancer: From Discovery to Action.” Mol Biol Evol, vol. 37, no. 2, Feb. 2020, pp. 320–26. Pubmed, doi:10.1093/molbev/msz242.
Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 Feb 1;37(2):320–326.
Published In
Mol Biol Evol
DOI
EISSN
1537-1719
Publication Date
February 1, 2020
Volume
37
Issue
2
Start / End Page
320 / 326
Location
United States
Related Subject Headings
- Stem Cell Niche
- Phylogeny
- Neoplasms
- Humans
- Genomics
- Genetic Fitness
- Evolutionary Biology
- Evolution, Molecular
- Disease Progression
- 3105 Genetics