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Topography and pachymetry maps for mouse corneas using optical coherence tomography.

Publication ,  Journal Article
Liu, AS; Brown, DM; Conn, RE; McNabb, RP; Pardue, MT; Kuo, AN
Published in: Experimental eye research
January 2020

The majority of the eye's refractive power lies in the cornea, and pathological changes in its shape can affect vision. Small animal models offer an unparalleled degree of control over genetic and environmental factors that can help elucidate mechanisms of diseases affecting corneal shape. However, there is not currently a method to characterize the corneal shape of small animal eyes with topography or pachymetry maps, as is done clinically for humans. We bridge this gap by demonstrating methods using optical coherence tomography (OCT) to generate the first topography and pachymetry (thickness) maps of mouse corneas. Radii of curvature acquired using OCT were validated using calibration spheres as well as in vivo mouse corneas with a mouse keratometer. The resulting topography and pachymetry maps are analogous to those used diagnostically in clinic and potentially allow for characterization of genetically modified mice that replicate key features of human corneal disease.

Duke Scholars

Published In

Experimental eye research

DOI

EISSN

1096-0007

ISSN

0014-4835

Publication Date

January 2020

Volume

190

Start / End Page

107868

Related Subject Headings

  • Tomography, Optical Coherence
  • Ophthalmology & Optometry
  • Models, Theoretical
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Corneal Topography
  • Corneal Pachymetry
  • Cornea
  • Biometry
 

Citation

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Liu, A. S., Brown, D. M., Conn, R. E., McNabb, R. P., Pardue, M. T., & Kuo, A. N. (2020). Topography and pachymetry maps for mouse corneas using optical coherence tomography. Experimental Eye Research, 190, 107868. https://doi.org/10.1016/j.exer.2019.107868
Liu, Alice S., Dillon M. Brown, Rachel E. Conn, Ryan P. McNabb, Machelle T. Pardue, and Anthony N. Kuo. “Topography and pachymetry maps for mouse corneas using optical coherence tomography.Experimental Eye Research 190 (January 2020): 107868. https://doi.org/10.1016/j.exer.2019.107868.
Liu AS, Brown DM, Conn RE, McNabb RP, Pardue MT, Kuo AN. Topography and pachymetry maps for mouse corneas using optical coherence tomography. Experimental eye research. 2020 Jan;190:107868.
Liu, Alice S., et al. “Topography and pachymetry maps for mouse corneas using optical coherence tomography.Experimental Eye Research, vol. 190, Jan. 2020, p. 107868. Epmc, doi:10.1016/j.exer.2019.107868.
Liu AS, Brown DM, Conn RE, McNabb RP, Pardue MT, Kuo AN. Topography and pachymetry maps for mouse corneas using optical coherence tomography. Experimental eye research. 2020 Jan;190:107868.
Journal cover image

Published In

Experimental eye research

DOI

EISSN

1096-0007

ISSN

0014-4835

Publication Date

January 2020

Volume

190

Start / End Page

107868

Related Subject Headings

  • Tomography, Optical Coherence
  • Ophthalmology & Optometry
  • Models, Theoretical
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Corneal Topography
  • Corneal Pachymetry
  • Cornea
  • Biometry