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Hydrogel microparticles for biomedical applications.

Publication ,  Journal Article
Daly, AC; Riley, L; Segura, T; Burdick, JA
Published in: Nature reviews. Materials
January 2020

Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and bioinks for 3D printing. Biologics (cells and drugs) can be encapsulated into HMPs of predefined shapes and sizes using a variety of fabrication techniques (batch emulsion, microfluidics, lithography, electrohydrodynamic (EHD) spraying and mechanical fragmentation). HMPs can be formulated in suspensions to deliver therapeutics, as aggregates of particles (granular hydrogels) to form microporous scaffolds that promote cell infiltration or embedded within a bulk hydrogel to obtain multiscale behaviours. HMP suspensions and granular hydrogels can be injected for minimally invasive delivery of biologics, and they exhibit modular properties when comprised of mixtures of distinct HMP populations. In this Review, we discuss the fabrication techniques that are available for fabricating HMPs, as well as the multiscale behaviours of HMP systems and their functional properties, highlighting their advantages over traditional bulk hydrogels. Furthermore, we discuss applications of HMPs in the fields of cell delivery, drug delivery, scaffold design and biofabrication.

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Published In

Nature reviews. Materials

DOI

EISSN

2058-8437

ISSN

2058-8437

Publication Date

January 2020

Volume

5

Issue

1

Start / End Page

20 / 43

Related Subject Headings

  • 4016 Materials engineering
 

Citation

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Chicago
ICMJE
MLA
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Daly, A. C., Riley, L., Segura, T., & Burdick, J. A. (2020). Hydrogel microparticles for biomedical applications. Nature Reviews. Materials, 5(1), 20–43. https://doi.org/10.1038/s41578-019-0148-6
Daly, Andrew C., Lindsay Riley, Tatiana Segura, and Jason A. Burdick. “Hydrogel microparticles for biomedical applications.Nature Reviews. Materials 5, no. 1 (January 2020): 20–43. https://doi.org/10.1038/s41578-019-0148-6.
Daly AC, Riley L, Segura T, Burdick JA. Hydrogel microparticles for biomedical applications. Nature reviews Materials. 2020 Jan;5(1):20–43.
Daly, Andrew C., et al. “Hydrogel microparticles for biomedical applications.Nature Reviews. Materials, vol. 5, no. 1, Jan. 2020, pp. 20–43. Epmc, doi:10.1038/s41578-019-0148-6.
Daly AC, Riley L, Segura T, Burdick JA. Hydrogel microparticles for biomedical applications. Nature reviews Materials. 2020 Jan;5(1):20–43.

Published In

Nature reviews. Materials

DOI

EISSN

2058-8437

ISSN

2058-8437

Publication Date

January 2020

Volume

5

Issue

1

Start / End Page

20 / 43

Related Subject Headings

  • 4016 Materials engineering