The Enigma of CRB1 and CRB1 Retinopathies.
Publication
, Journal Article
Ray, TA; Cochran, KJ; Kay, JN
Published in: Adv Exp Med Biol
2019
Mutations in the gene Crumbs homolog 1 (CRB1) are responsible for several retinopathies that are diverse in severity and phenotype. Thus, there is considerable incentive to determine how disruption of this gene causes disease. Progress on this front will aid in developing molecular diagnostics that can predict disease severity with the ultimate goal of developing therapies for CRB1 retinopathies via gene replacement. The purpose of this review is to summarize what is known regarding CRB1 and highlights information outstanding. Doing so will provide a framework toward a thorough understanding of CRB1 at the molecular and protein level with the ultimate goal of deciphering how it contributes to the disease.
Duke Scholars
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Published In
Adv Exp Med Biol
DOI
ISSN
0065-2598
Publication Date
2019
Volume
1185
Start / End Page
251 / 255
Location
United States
Related Subject Headings
- Retinal Diseases
- Paraneoplastic Syndromes, Ocular
- Nerve Tissue Proteins
- Mutation
- Mice, Knockout
- Mice
- Membrane Proteins
- Humans
- General & Internal Medicine
- Eye Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Ray, T. A., Cochran, K. J., & Kay, J. N. (2019). The Enigma of CRB1 and CRB1 Retinopathies. Adv Exp Med Biol, 1185, 251–255. https://doi.org/10.1007/978-3-030-27378-1_41
Ray, Thomas A., Kelly J. Cochran, and Jeremy N. Kay. “The Enigma of CRB1 and CRB1 Retinopathies.” Adv Exp Med Biol 1185 (2019): 251–55. https://doi.org/10.1007/978-3-030-27378-1_41.
Ray TA, Cochran KJ, Kay JN. The Enigma of CRB1 and CRB1 Retinopathies. Adv Exp Med Biol. 2019;1185:251–5.
Ray, Thomas A., et al. “The Enigma of CRB1 and CRB1 Retinopathies.” Adv Exp Med Biol, vol. 1185, 2019, pp. 251–55. Pubmed, doi:10.1007/978-3-030-27378-1_41.
Ray TA, Cochran KJ, Kay JN. The Enigma of CRB1 and CRB1 Retinopathies. Adv Exp Med Biol. 2019;1185:251–255.
Published In
Adv Exp Med Biol
DOI
ISSN
0065-2598
Publication Date
2019
Volume
1185
Start / End Page
251 / 255
Location
United States
Related Subject Headings
- Retinal Diseases
- Paraneoplastic Syndromes, Ocular
- Nerve Tissue Proteins
- Mutation
- Mice, Knockout
- Mice
- Membrane Proteins
- Humans
- General & Internal Medicine
- Eye Proteins