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Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.

Publication ,  Journal Article
Urata, CN; Mariottoni, EB; Jammal, AA; Ogata, NG; Thompson, AC; Berchuck, SI; Estrela, T; Medeiros, FA
Published in: Am J Ophthalmol
February 2020

PURPOSE: To assess short- and long-term variability on standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT) in glaucoma. DESIGN: Prospective cohort. METHODS: Ordinary least squares linear regression of SAP mean deviation (MD) and SD-OCT global retinal nerve fiber layer (RNFL) thickness were fitted over time for sequential tests conducted within 5 weeks (short-term testing) and annually (long-term testing). Residuals were obtained by subtracting the predicted and observed values, and each patient's standard deviation (SD) of the residuals was used as a measure of variability. Wilcoxon signed-rank test was performed to test the hypothesis of equality between short- and long-term variability. RESULTS: A total of 43 eyes of 43 glaucoma subjects were included. Subjects had a mean 4.5 ± 0.8 SAP and OCT tests for short-term variability assessment. For long-term variability, the same number of tests were performed and results annually collected over an average of 4.0 ± 0.8 years. The average SD of the residuals was significantly higher in the long-term than in the short-term period for both tests: 1.05 ± 0.70 dB vs. 0.61 ± 0.34 dB, respectively (P < 0.001) for SAP MD and 1.95 ± 1.86 μm vs. 0.81 ± 0.56 μm, respectively (P < 0.001) for SD-OCT RNFL thickness. CONCLUSIONS: Long-term variability was higher than short-term variability on SD-OCT and SAP. Because current event-based algorithms for detection of glaucoma progression on SAP and SD-OCT have relied on short-term variability data to establish their normative databases, these algorithms may be underestimating the variability in the long-term and thus may overestimate progression over time.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

February 2020

Volume

210

Start / End Page

19 / 25

Location

United States

Related Subject Headings

  • Visual Field Tests
  • Tomography, Optical Coherence
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Glaucoma
  • Female
  • Disease Progression
 

Citation

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Urata, C. N., Mariottoni, E. B., Jammal, A. A., Ogata, N. G., Thompson, A. C., Berchuck, S. I., … Medeiros, F. A. (2020). Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma. Am J Ophthalmol, 210, 19–25. https://doi.org/10.1016/j.ajo.2019.10.034
Urata, Carla N., Eduardo B. Mariottoni, Alessandro A. Jammal, Nara G. Ogata, Atalie C. Thompson, Samuel I. Berchuck, Tais Estrela, and Felipe A. Medeiros. “Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.Am J Ophthalmol 210 (February 2020): 19–25. https://doi.org/10.1016/j.ajo.2019.10.034.
Urata CN, Mariottoni EB, Jammal AA, Ogata NG, Thompson AC, Berchuck SI, et al. Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma. Am J Ophthalmol. 2020 Feb;210:19–25.
Urata, Carla N., et al. “Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.Am J Ophthalmol, vol. 210, Feb. 2020, pp. 19–25. Pubmed, doi:10.1016/j.ajo.2019.10.034.
Urata CN, Mariottoni EB, Jammal AA, Ogata NG, Thompson AC, Berchuck SI, Estrela T, Medeiros FA. Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma. Am J Ophthalmol. 2020 Feb;210:19–25.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

February 2020

Volume

210

Start / End Page

19 / 25

Location

United States

Related Subject Headings

  • Visual Field Tests
  • Tomography, Optical Coherence
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Glaucoma
  • Female
  • Disease Progression