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Moving into the cell: single-molecule studies of molecular motors in complex environments.

Publication ,  Journal Article
Veigel, C; Schmidt, CF
Published in: Nature reviews. Molecular cell biology
March 2011

Much has been learned in the past decades about molecular force generation. Single-molecule techniques, such as atomic force microscopy, single-molecule fluorescence microscopy and optical tweezers, have been key in resolving the mechanisms behind the power strokes, 'processive' steps and forces of cytoskeletal motors. However, it remains unclear how single force generators are integrated into composite mechanical machines in cells to generate complex functions such as mitosis, locomotion, intracellular transport or mechanical sensory transduction. Using dynamic single-molecule techniques to track, manipulate and probe cytoskeletal motor proteins will be crucial in providing new insights.

Duke Scholars

Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

March 2011

Volume

12

Issue

3

Start / End Page

163 / 176

Related Subject Headings

  • Single-Cell Analysis
  • Scattering, Radiation
  • Quantum Dots
  • Optical Tweezers
  • Molecular Motor Proteins
  • Models, Biological
  • Microscopy, Fluorescence
  • Microscopy, Atomic Force
  • Light
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Veigel, C., & Schmidt, C. F. (2011). Moving into the cell: single-molecule studies of molecular motors in complex environments. Nature Reviews. Molecular Cell Biology, 12(3), 163–176. https://doi.org/10.1038/nrm3062
Veigel, Claudia, and Christoph F. Schmidt. “Moving into the cell: single-molecule studies of molecular motors in complex environments.Nature Reviews. Molecular Cell Biology 12, no. 3 (March 2011): 163–76. https://doi.org/10.1038/nrm3062.
Veigel C, Schmidt CF. Moving into the cell: single-molecule studies of molecular motors in complex environments. Nature reviews Molecular cell biology. 2011 Mar;12(3):163–76.
Veigel, Claudia, and Christoph F. Schmidt. “Moving into the cell: single-molecule studies of molecular motors in complex environments.Nature Reviews. Molecular Cell Biology, vol. 12, no. 3, Mar. 2011, pp. 163–76. Epmc, doi:10.1038/nrm3062.
Veigel C, Schmidt CF. Moving into the cell: single-molecule studies of molecular motors in complex environments. Nature reviews Molecular cell biology. 2011 Mar;12(3):163–176.

Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

March 2011

Volume

12

Issue

3

Start / End Page

163 / 176

Related Subject Headings

  • Single-Cell Analysis
  • Scattering, Radiation
  • Quantum Dots
  • Optical Tweezers
  • Molecular Motor Proteins
  • Models, Biological
  • Microscopy, Fluorescence
  • Microscopy, Atomic Force
  • Light
  • Humans