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Structural and mechanical study of a self-assembling protein nanotube.

Publication ,  Journal Article
Graveland-Bikker, JF; Schaap, IAT; Schmidt, CF; de Kruif, CG
Published in: Nano letters
April 2006

We report a structural characterization of self-assembling nanostructures. Using atomic force microscopy (AFM), we discovered that partially hydrolyzed alpha-lactalbumin organizes in a 10-start helix forming tubes with diameters of only 21 nm. We probed the mechanical strength of these nanotubes by locally indenting them with an AFM tip. To extract the material properties of the nanotubes, we modeled the experiment using finite element methods. Our study shows that artificial helical protein self-assembly can yield very stable, strong structures that can function either as a model system for artificial self-assembly or as a nanostructure with potential for practical applications.

Duke Scholars

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

April 2006

Volume

6

Issue

4

Start / End Page

616 / 621

Related Subject Headings

  • Tensile Strength
  • Stress, Mechanical
  • Protein Conformation
  • Protein Binding
  • Particle Size
  • Nanotubes
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Multiprotein Complexes
  • Models, Chemical
 

Citation

APA
Chicago
ICMJE
MLA
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Graveland-Bikker, J. F., Schaap, I. A. T., Schmidt, C. F., & de Kruif, C. G. (2006). Structural and mechanical study of a self-assembling protein nanotube. Nano Letters, 6(4), 616–621. https://doi.org/10.1021/nl052205h
Graveland-Bikker, J. F., I. A. T. Schaap, C. F. Schmidt, and C. G. de Kruif. “Structural and mechanical study of a self-assembling protein nanotube.Nano Letters 6, no. 4 (April 2006): 616–21. https://doi.org/10.1021/nl052205h.
Graveland-Bikker JF, Schaap IAT, Schmidt CF, de Kruif CG. Structural and mechanical study of a self-assembling protein nanotube. Nano letters. 2006 Apr;6(4):616–21.
Graveland-Bikker, J. F., et al. “Structural and mechanical study of a self-assembling protein nanotube.Nano Letters, vol. 6, no. 4, Apr. 2006, pp. 616–21. Epmc, doi:10.1021/nl052205h.
Graveland-Bikker JF, Schaap IAT, Schmidt CF, de Kruif CG. Structural and mechanical study of a self-assembling protein nanotube. Nano letters. 2006 Apr;6(4):616–621.
Journal cover image

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

April 2006

Volume

6

Issue

4

Start / End Page

616 / 621

Related Subject Headings

  • Tensile Strength
  • Stress, Mechanical
  • Protein Conformation
  • Protein Binding
  • Particle Size
  • Nanotubes
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Multiprotein Complexes
  • Models, Chemical