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High-resolution probing of cellular force transmission.

Publication ,  Journal Article
Mizuno, D; Bacabac, R; Tardin, C; Head, D; Schmidt, CF
Published in: Physical review letters
April 2009

Cells actively probe mechanical properties of their environment by exerting internally generated forces. The response they encounter profoundly affects their behavior. Here we measure in a simple geometry the forces a cell exerts suspended by two optical traps. Our assay quantifies both the overall force and the fraction of that force transmitted to the environment. Mimicking environments of varying stiffness by adjusting the strength of the traps, we found that the force transmission is highly dependent on external compliance. This suggests a calibration mechanism for cellular mechanosensing.

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Published In

Physical review letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

April 2009

Volume

102

Issue

16

Start / End Page

168102

Related Subject Headings

  • Rheology
  • Models, Biological
  • Microscopy, Interference
  • Mechanotransduction, Cellular
  • General Physics
  • Biomechanical Phenomena
  • Biological Assay
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
 

Citation

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Mizuno, D., Bacabac, R., Tardin, C., Head, D., & Schmidt, C. F. (2009). High-resolution probing of cellular force transmission. Physical Review Letters, 102(16), 168102. https://doi.org/10.1103/physrevlett.102.168102
Mizuno, Daisuke, Rommel Bacabac, Catherine Tardin, David Head, and Christoph F. Schmidt. “High-resolution probing of cellular force transmission.Physical Review Letters 102, no. 16 (April 2009): 168102. https://doi.org/10.1103/physrevlett.102.168102.
Mizuno D, Bacabac R, Tardin C, Head D, Schmidt CF. High-resolution probing of cellular force transmission. Physical review letters. 2009 Apr;102(16):168102.
Mizuno, Daisuke, et al. “High-resolution probing of cellular force transmission.Physical Review Letters, vol. 102, no. 16, Apr. 2009, p. 168102. Epmc, doi:10.1103/physrevlett.102.168102.
Mizuno D, Bacabac R, Tardin C, Head D, Schmidt CF. High-resolution probing of cellular force transmission. Physical review letters. 2009 Apr;102(16):168102.

Published In

Physical review letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

April 2009

Volume

102

Issue

16

Start / End Page

168102

Related Subject Headings

  • Rheology
  • Models, Biological
  • Microscopy, Interference
  • Mechanotransduction, Cellular
  • General Physics
  • Biomechanical Phenomena
  • Biological Assay
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering