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Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots.

Publication ,  Journal Article
Chizhik, AM; Stein, S; Dekaliuk, MO; Battle, C; Li, W; Huss, A; Platen, M; Schaap, IAT; Gregor, I; Demchenko, AP; Schmidt, CF; Enderlein, J ...
Published in: Nano letters
January 2016

Success in super-resolution imaging relies on a proper choice of fluorescent probes. Here, we suggest novel easily produced and biocompatible nanoparticles-carbon nanodots-for super-resolution optical fluctuation bioimaging (SOFI). The particles revealed an intrinsic dual-color fluorescence, which corresponds to two subpopulations of particles of different electric charges. The neutral nanoparticles localize to cellular nuclei suggesting their potential use as an inexpensive, easily produced nucleus-specific label. The single particle study revealed that the carbon nanodots possess a unique hybrid combination of fluorescence properties exhibiting characteristics of both dye molecules and semiconductor nanocrystals. The results suggest that charge trapping and redistribution on the surface of the particles triggers their transitions between emissive and dark states. These findings open up new possibilities for the utilization of carbon nanodots in the various super-resolution microscopy methods based on stochastic optical switching.

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Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

January 2016

Volume

16

Issue

1

Start / End Page

237 / 242

Related Subject Headings

  • Quantum Dots
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Molecular Imaging
  • Microtubules
  • Fluorescent Dyes
  • Cell Nucleus
  • Carbon
 

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Chizhik, A. M., Stein, S., Dekaliuk, M. O., Battle, C., Li, W., Huss, A., … Chizhik, A. I. (2016). Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots. Nano Letters, 16(1), 237–242. https://doi.org/10.1021/acs.nanolett.5b03609
Chizhik, Anna M., Simon Stein, Mariia O. Dekaliuk, Christopher Battle, Weixing Li, Anja Huss, Mitja Platen, et al. “Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots.Nano Letters 16, no. 1 (January 2016): 237–42. https://doi.org/10.1021/acs.nanolett.5b03609.
Chizhik AM, Stein S, Dekaliuk MO, Battle C, Li W, Huss A, et al. Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots. Nano letters. 2016 Jan;16(1):237–42.
Chizhik, Anna M., et al. “Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots.Nano Letters, vol. 16, no. 1, Jan. 2016, pp. 237–42. Epmc, doi:10.1021/acs.nanolett.5b03609.
Chizhik AM, Stein S, Dekaliuk MO, Battle C, Li W, Huss A, Platen M, Schaap IAT, Gregor I, Demchenko AP, Schmidt CF, Enderlein J, Chizhik AI. Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots. Nano letters. 2016 Jan;16(1):237–242.
Journal cover image

Published In

Nano letters

DOI

EISSN

1530-6992

ISSN

1530-6984

Publication Date

January 2016

Volume

16

Issue

1

Start / End Page

237 / 242

Related Subject Headings

  • Quantum Dots
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Molecular Imaging
  • Microtubules
  • Fluorescent Dyes
  • Cell Nucleus
  • Carbon