
Microfluidic device for chemical and mechanical manipulation of suspended cells
Publication
, Journal Article
Rezvani, S; Shi, N; Squires, TM; Schmidt, CF
Published in: Journal of Physics D: Applied Physics
January 10, 2018
Microfluidic devices have proven to be useful and versatile for cell studies. We here report on a method to adapt microfluidic stickers made from UV-curable optical adhesive with inserted permeable hydrogel membrane micro-windows for mechanical studies of suspended cells. The windows were fabricated by optical projection lithography using scanning confocal microscopy. The device allows us to rapidly exchange embedding medium while observing and probing the cells. We characterize the device and demonstrate the function by exposing cultured fibroblasts to varying osmotic conditions. Cells can be shrunk reversibly under osmotic compression.
Duke Scholars
Published In
Journal of Physics D: Applied Physics
DOI
EISSN
1361-6463
ISSN
0022-3727
Publication Date
January 10, 2018
Volume
51
Issue
4
Related Subject Headings
- Applied Physics
- 51 Physical sciences
- 40 Engineering
- 09 Engineering
- 02 Physical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Rezvani, S., Shi, N., Squires, T. M., & Schmidt, C. F. (2018). Microfluidic device for chemical and mechanical manipulation of suspended cells. Journal of Physics D: Applied Physics, 51(4). https://doi.org/10.1088/1361-6463/aaa121
Rezvani, S., N. Shi, T. M. Squires, and C. F. Schmidt. “Microfluidic device for chemical and mechanical manipulation of suspended cells.” Journal of Physics D: Applied Physics 51, no. 4 (January 10, 2018). https://doi.org/10.1088/1361-6463/aaa121.
Rezvani S, Shi N, Squires TM, Schmidt CF. Microfluidic device for chemical and mechanical manipulation of suspended cells. Journal of Physics D: Applied Physics. 2018 Jan 10;51(4).
Rezvani, S., et al. “Microfluidic device for chemical and mechanical manipulation of suspended cells.” Journal of Physics D: Applied Physics, vol. 51, no. 4, Jan. 2018. Scopus, doi:10.1088/1361-6463/aaa121.
Rezvani S, Shi N, Squires TM, Schmidt CF. Microfluidic device for chemical and mechanical manipulation of suspended cells. Journal of Physics D: Applied Physics. 2018 Jan 10;51(4).

Published In
Journal of Physics D: Applied Physics
DOI
EISSN
1361-6463
ISSN
0022-3727
Publication Date
January 10, 2018
Volume
51
Issue
4
Related Subject Headings
- Applied Physics
- 51 Physical sciences
- 40 Engineering
- 09 Engineering
- 02 Physical Sciences